Fibrous Dysplasia of Bone (Subscribe)  

Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Fibrous dyplasia From Wikibooks, the open-content textbooks collection Fibrous dysplasia is a benign, developmental anomaly of the bone-forming mesenchyme in which the medullary cavity is replaced with fibrous material, woven bone, and spindle cells. Virtually any bone in the body can be affected. It is a nonhereditary disorder of...

Mazabraud's syndrome is a rare entity represented by the association of fibrous dysplasia and intramuscular myxomas. Their association was first reported in 1957 by A. Mazabraud, a French physican.[1] Mazabraud's syndrome does not appear to be hereditary and occurs mostly in women. The myxomas tend to develop and congregate around...

* xray: "ground glass" lesion with sclerotic rim
* may be expansile, predominantly metaphysis to diaphysis
* labs: increased alk phos, o/w normal
* monostotic form
o any bone (ribs, femur, tibia most common)
o...

Author: Mark Clayer, MD, MBBS, FRACS, FAOrthA, Head of Musculoskeletal Tumor Service, Department of Orthopaedics and Trauma, Queen Elizabeth Hospital; Senior Visiting Medical Specialist, Royal Adelaide Hospital and Women's and Children's Fibrous dysplasia is a developmental dysplastic disorder of bone in which immature woven bone is formed directly from abnormal fibrous...

Author: Mahesh Kumar Neelala Anand, MBBS, DNB, FRCR, Consulting Staff, Department of Radiology, Pennine Acute Hospitals NHS Trust, Royal Oldham Hospital, Manchester, UK Background: Fibrous dysplasia is a skeletal developmental anomaly of the bone-forming mesenchyme that manifests as a defect in osteoblastic differentiation and maturation. Virtually any bone in the body...

Fibrous Dysplasia is a disease that causes growths or lesions in one (monostotic) or more (polyostotic) bones of the human body. These lesions are tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and fibrous dysplasia bone cysts weakening of the areas of...

The name fibrous dysplasia was coined by Lichtenstein in 1938 to describe a disorder of expanding fibro-osseous lesions that had been referred to as fibrous osteodystrophy, osteodystrophia fibrosa and osteitis fibrosa disseminata. Its etiology is unknown; however, the most widely accepted theory is that it is a developmental abnormality of...

General Discussion Fibrous dysplasia is a term that refers to either a group of chronic conditions featuring cystic bone growth that may arise from abnormal bone development or to a disease of bone marrow (medullary bone) characterized by benign cysts. Fibrous dysplasia is characterized by uneven growth, pain, brittleness, and deformity...

Objectives
1. Describe differing patterns of involvement noted in patients having fibrous dysplasia of bone
2. Describe the pathology of fibrous dysplasia
3. Discuss the genetic anomalies associated with fibrous dysplasia
4. Discuss the natural history and results of treatment of bony...

Discussion: - results from a defect is somatic mutation in the gene coding for alpha subunit of Gs, the G protein that stimulates cAMP formation; - overproduction of cAMP, causes overexpression of c-fos, which regulates proliferation...

Pictorial Essay AJR 2004; 182:1389-1398 Imaging Findings of Fibrous Dysplasia with Histopathologic and Intraoperative Correlation Kimberly A. Fitzpatrick1, Mihra S. Taljanovic1, Donald P. Speer2, Anna R. Graham3, Jon A. Jacobson4, George R. Barnes1 and Tim B. Hunter1 1 Department of Radiology, University of Arizona College of Medicine, 1501 N Campbell Ave.,...

lion-like facies
* form of polyostotic fibrous dysplasia
* involves skull and facial bones

Osteofibrous dysplasia is a rare condition that most commonly affects the tibia (see Image 1). Osteofibrous dysplasia is a nonneoplastic lesion that is frequently asymptomatic and has an unknown etiology. Most lesions of osteofibrous dysplasia affect the cortex of the tibia, predominantly the middle third of the diaphysis. The cortex often...

MedscapeMedscape Family Medicine/Primary Care. 2000;2(2) ©2000 I have a patient with the radiologic diagnosis of fibrous dysplasia. Is this entity in the differential diagnosis of Paget's disease? If so, is treatment with pamidronate indicated?

fibrous dysplasia