fibrous dysplasia CHORUS

Description: * xray: "ground glass" lesion with sclerotic rim
* may be expansile, predominantly metaphysis to diaphysis
* labs: increased alk phos, o/w normal
* monostotic form
o any bone (ribs, femur, tibia most common)
o diametaphyseal
* polyostotic form
o unilateral predominance
o not familial (except cherubism)
o scalloping, expansion, deformity (Shepherd's crook)
* other forms
o McCune-Albright syndrome (with precocious puberty)
o leontiasis ossea (involves skull and facial bones)
o cherubism (hereditary form, involves mandible)