Acromegaly (Subscribe)  

acromegaly excess growth hormone due to eosinophilic adenoma/hyperplasia

Abstract The etiology of slipped capital femoral epiphysis is still unknown. Traumatic, endocrine, toxic, and mechanical causes have all been hypothesized. It is well documented that the highest incidence occurs during the adolescent growth spurt, suggesting the role of an endocrine abnormality. We report a case that supports this hypothesis Skeletal...

Author: Gabriel I Uwaifo, MBBS, Clinical and Research Attending, MedStar Clinical Research Center, Assistant Professor of Medicine and Endocrinology, The MedStar Research Institute and the Washington Hospital Center Coauthor(s): Nicholas J Sarlis, MBBS, MD, PhD, FACP, Medical Director, Department of Oncology-US Medical Affairs Department, Sanofi-Aventis Pharmaceuticals Background McCune-Albright syndrome (MAS) is defined as...

Alternative titles; symbols ALBRIGHT SYNDROME POLYOSTOTIC FIBROUS DYSPLASIA; PFD; POFD this phenotype is associated with mutations in the GNAS1 gene (139320). The McCune-Albright syndrome, usually caused by mosaicism for a mutation in the GNAS1 gene, is characterized by polyostotic fibrous dysplasia, pigment patches of the skin and endocrinologic abnormalities, including precocious puberty, thyrotoxicosis,...

Synonyms MAS Albright Syndrome Osteitis Fibrosa Disseminata Polyostotic, Fibrous Dysplasia PFD Precocious Puberty with Polyostotic Fibrosis and Abnormal Pigmentation POFD General Discussion McCune-Albright Syndrome (MAS) is a rare multisystem disorder characterized by (1) replacement of normal bone tissue with areas of abnormal fibrous growth (fibrous dysplasia); (2) patches of abnormal...

We examined prospectively 37 acromegalic patients with no history of polyneuropathy, acute trauma at the elbow, no diabetes or hypothyroidism with clinical examination, nerve conduction studies (NCS), and high-resolution ultrasound (US).
In 8 of 37 patients, a diagnosis of UCT was made at the beginning of the study reflecting a...