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Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic...

Avoiding postoperative delirium would require anesthetics that preserve cerebral autoregulation. However, that seems a quixotic goal given the intimate connection between neuronal activity and the surrounding capillary network. Perhaps the best approach currently is to avoid other pre-operative medications that disrupt cerebral autoregulation, although such nuances are at the frontier...

Editors' note: this is a plan of a study not the study itself
Delirum is common in hospitalized elderly patients and may be associated with increased morbidity, length of stay and patient care costs. Delirium (acute confusional state) is defined as an acute disorder of attention and cognition. In elderly patients,...

Delirium is a common but often undiagnosed complication in the elderly following a major operation. Recognizing the presentation of delirium and the criteria to establish the diagnosis of delirium will improve a clinician’s ability to detect this complication. Treating delirium with environmental, supportive, and pharmacologic interventions reduces the incidence and...

Trials Register
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves overall pain control.
Ottawa Hospital Research Institute Pfizer

Delirium is a common postoperative complication in older adults associated with adverse events including functional decline, longer lengths of stay, and risk of institutionalization. The purpose of this article is to systematically review preoperative risk factors associated with delirium following noncardiac surgery.
A medical literature search was conducted using several bibliographic...

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"confusion"[Majr] AND (jrid22024 OR jrid2275 OR jrid2208 OR jrid32471 OR jrid3046 OR jrid1981 OR jrid22800 OR jrid22785 OR jrid3221 OR jrid6314 OR jrid20148 OR jrid3758 OR jrid32378 OR jrid32364 OR jrid147 OR jrid30151 OR jrid148 OR jrid149 OR jrid352 OR...

Objectives: To evaluate risk factors for postoperative delirium in a cohort of elderly hip-surgery patients and to validate a medical risk stratification model.
Results: Incidence of delirium was 3.8% in the low-risk group (P <.001), 11.1% in the intermediate-risk group (P = .27, relative risk (RR) = 3.0), and 37.1%...