New thinking about postoperative delirium

Description: Avoiding postoperative delirium would require anesthetics that preserve cerebral autoregulation. However, that seems a quixotic goal given the intimate connection between neuronal activity and the surrounding capillary network. Perhaps the best approach currently is to avoid other pre-operative medications that disrupt cerebral autoregulation, although such nuances are at the frontier of current vascular medicine research. Alas, I can't think of a medication that enhances cerebral autoregulation.
New thinking about postoperative delirium Donald Redelmeier, MD MS(HSR) CMAJ • August 14, 2007; 177 (4) full text