Synovial Sarcoma (Subscribe)  

Question A 24-year-old female underwent excision of a 3-cm monophasic synovial sarcoma in the posterior low neck in Mexico. The tumor had 5 mitoses/10 hpf. The patient underwent another wide re-excision in the United States with no evidence of sarcoma in the specimen. The metastatic workup was negative. Does she need...

Synovial cell sarcoma is a rare soft-tissue tumor that is unrelated to synovial fluid and can occur in almost any part of the body. The majority of tumors occur in para-articular structures in the extremities;most are localized at diagnosis. These malignant, high-grade, soft-tissue neoplasms account for 7%-8% of all malignant...

Diagnostic Dilemmas Small-cell variant of synovial sarcoma: Fine-needle aspiration with ancillary features and potential diagnostic pitfalls Jan F. Silverman, M.D. 1 *, Rodney J. Landreneau, M.D. 2, Charles D. Sturgis, M.D. 1, Stephen S. Raab, M.D. 1, Karl R. Fox, M.D. 1, Katherine M. Jasnosz, M.D. 1, David J. Dabbs, M.D....

Contents - Author Information; Introduction; Relevant Anatomy And Contraindications; Workup; Treatment; Complications; Outcome And Prognosis; Future And Controversies; Pictures; Bibliography
Synovial sarcoma is a rare soft tissue sarcoma with features of epithelial differentiation. In contrast with its name, synovial sarcoma is not associated with synovial joints. It tends to arise in...

rare soft tissue tumor, it accounts for up to 5 to 8% of soft tissue sarcomas , the fourth most common type of sarcoma after malignant fibrous histyocytoma, liposarcoma and rhabdomyosarcoma ; the most common pediatric non rhabdomyosarcomatous soft tissue cancer; average incidence : 2,75 per 100000 population based on...

soft-tissue mass, usually about 1 cm from joint
*amorphous calcifications (33%)
*most common at knee
*bone erosion (wide zone of transition)
*juxta-articular osteoporosis

This is one of the sarcomas that combine histologic features of both a carcinoma and a sarcoma. It may have epithelioid cells, mimicking carcinoma, intimately admixed with spindled sarcoma cells. Because of these features, the pathologist may have to differentiate between a poorly differentiated carcinoma and this tumor. It is...

Contents Introduction Differentials Radiograph CT SCAN Mri Ultrasound Nuclear Medicine Angiography Intervention Multimedia References
Synovial sarcoma comprises 8-10% of all sarcomas and most commonly affects adults in the third-to-fifth decades of life. The malignancy most commonly involves the extremities, especially the lower extremities around the knees. Synovial sarcoma frequently is...

Synovial sarcoma is a well defined entity which commonly occurs in adolescents and young adults. (between 15 and 40 years of age).
This tumour is commonly located in the paraarticular regions, close to tendon sheaths, bursae and joint capsules. The tumour rarely involves synovial membrane.
Site: These are usually located ...

History: For 2 weeks, a painless swelling in the left cervical area and in the suprapit. Surgical aspiration of the mass. Diagnosis: hematoma. After 6 months, severely increased swelling.

Radiology Picture of the Day June 2007.
This 35yr old patient presented with swelling on the back of his knee for 6 months. The swelling is not particularly tender and was initially discovered incidentally.

Write-up by Dr Antonio Ruggerio, Division of Pediatric Oncology, Catholic University of Roma

Illustrated cases

reference

Synovial sarcoma is a rare soft-tissue sarcoma defined by the presence of a unique translocation, t(X;18)(q11.2;p11.2). It usually occurs adjacent to joints in the limbs and was originally thought to arise from synovium. However, synovial sarcoma is a misnomer and the origin of the tissue is unknown. Primary synovial sarcomas have...