Rickets (Subscribe)  

Several diseases can result in defective mineralization of bone in children, including the following:
Rickets
Nutritional rickets
Congenital rickets
Rickets of prematurity
Genetic rickets
Neoplastic rickets
Hypophosphatemic rickets
Drug-induced rickets
Renal causes - Renal osteodystrophy, Fanconi syndrome
Tumor-induced osteomalacia
Other causes
Hypophosphatasia
McCune-Albright syndrome
Osteogenesis imperfecta with mineralization defect (syndrome resembling...

Wheeless' Textbook of Orthopaedics Discussion: - this is the most frequently encountered form of rickets and consists of a genetic or acquired fault in the handling of phosphate in the proximal tubule; -...

Osteopetrosis is an extremely rare inhereditory bone disorder, in which defective bone resorption by osteoclasts leads to excessive bone deposition. Though, there is usually calcium excess in osteopetrosis, rickets has been described rarely as a paradoxical complication of infantile osteopetrosis and it results from the inability of the osteoclasts to...

To analyse risk factors in rachitic Congolese children with serious deformities in their lower members and to describe the lesions.
RESULTS: The most frequent deformity was genu varum (58.2%), followed by windsept (23.7%) and genu valgum (13.9%). Genu varum predominated in girls of between 2-4 years (p=0.0025). We found florid rickets...

Lack of Vitamin D will reveal itself in those areas in the bone that show the greatest activity. Growth processes in the immature skeleton cause Rickets and structural responses to stress in the mature skeleton give rise to Osteomalacia. In the immature skeleton, the greatest activity is the ossification boundary...

Objectives
1. Outline the pathway of Vitamin D metabolism
2. Define: osteomalacia, rickets
3. Describe the clinical features of rickets
4. Describe the radiographic findings noted in patients with rickets, and their relationship with histologic findings
5. List causes of...

relative or absolute deficiency of vitamin D
* presents by 3-6 months, almost always <2 yrs
xray:
* loss of zone of provisional calcification
* wide physis (> 1 mm)(increased osteoid)
* cupping, fraying + irregularity of metaphyses
* bowing of long bones
* decreased bone density
* rachitic rosary
* periosteal reaction

Radiology case 438-571 Clinical presentation: Two and a half year old asian child, failure to walk and thrive.
There is widening of the epiphyseal plate with visible soft tissue swelling separating epiphyses and metaphyses. The metaphyses are broadened and cupped around the epiphyses, particularly of radius ulna and metacarpals. The provisional zone...

Radiology case 458-571 Clinical presentation: 3 year old child of recent immigrants from India, not walking properly.
There is a varus deformity of both legs with bowed tibiae. The epiphyseal plates are widened and all the metaphyses are broad and irregular, relative to the epiphyses. Additionally, the distal tibial metaphyses appear cupped...

Osteomalacia means "soft bones". The bones are about half mineral (calcium and phosphate) and half protein matrix, which is called osteoid. Normally 98% of the osteoid is mineralized, and 2% is new osteoid that has just been made and is waiting to get mineralized. In osteomalacia, the mineral does not...

Rickets - Paediatric disorder characterised by deformity and growth retardation secondary to defective mineralisation of the growth plate
Osteomalacia
- defective mineralisation of osteoid
- adults

Wheeless' Textbook of Orthopaedics See: - Osteomalacia: - Vit D Abnormalities: - Discussion: - rickets is an osteomalacic syndrome in which there is an inability to mineralize chondroid and osteoid; - lack of...

Fact sheet on Vitamin D

X-linked dominant defect in renal tubular resorption of phosphate
* presents in 1st yr
* progressive limb deformities
xray:
* less severe changes than other rickets
* presents later
DDx features:
* family hx
* normal serum calcium
* marked hypophosphatemia (decreased PO4)
* no secondary hyperPTH