Nerve Tissue Neoplasms (Subscribe)  

Alternative names NF1; Von Recklinghausen neurofibromatosis

Definition    Neurofibromatosis-1 is an inherited disorder, characterized by formation of neurofibromas (tumors involving nerve tissue) in the skin, subcutaneous tissue, cranial nerves, and spinal root nerves.

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Neurofibromatosis is a genetic disorder (can be passed from parent to child). Neurofibromatosis (NF) affects development and growth of nerve cell (neural) tissues. It causes tumors to grow on nerves (neurofibromas) on or under the skin anywhere in the body. The tumors are usually not cancerous (benign), but in some...

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Search of JBJS B site for articles on scoliosis in NF. Search string site:www.jbjs.org.uk dystrophic (curvature OR scoliosis) (neurofibroma OR neurofibromatosis)

Neurofibromatosis is an inherited disorder and is divided into two types. NF 1 is characterized by multiple neurofibromas, acoustic nerve schwannomas, gliomas of the optic nerve, meningiomas, pigmented nodules of the iris, and hyperpigmented spots on the skin (cafe au lait spots). It is associated with a gene on chromosome...

Neurofibromatosis is an autosomal dominant disorder that affects the bone, the nervous system, soft tissue, and the skin. At least 8 different clinical phenotypes of neurofibromatosis have been identified and are linked to at least 2 genetic disorders. Clinical manifestations increase over time. Neurologic problems and malignancy development may supervene.

Contents - Introduction Indications Relevant Anatomy And Contraindications Workup Treatment Complications Outcome And Prognosis Future And Controversies Bibliography
The intent of this article is to identify the complications most commonly associated with the orthopedic manifestations of neurofibromatosis and to present strategies for their management.

Neurofibromatosis in children: the role of the orthopaedist Crawford and Schorry J Am Acad Orthop Surg.1999; 7: 217-230
Abstract - Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is one of the most common human single-gene disorders, affecting at least 1 million persons throughout the world. It encompasses...

NF, Inc. is a national, tax-exempt, charitable organization whose mission is to create a community of support for those affected by NF, through education, advocacy, coalitions, and supporting research for treatments and a cure. We encourage you to explore our site, check back often, and contact us if you need...

Radiology case 38--1831 There is scalloping of the posterior margins of the vertebral bodies with a concave outline. There is enlargement of the neural foramina. The contrast of the myleogram fills sacculations of the theca.

Neurofibromatosis is a genetic disorder in which many soft, fleshy growths of nerve tissue (neurofibromas) grow under the skin and in other parts of the body.

Neurofibromatosis type 1 is a condition characterized by changes in skin coloring (pigmentation) and the growth of tumors along nerves in the skin, brain, and other parts of the body. The signs and symptoms of this condition vary widely among affected people. Beginning in early childhood, almost all people with neurofibromatosis...

Neurofibromatosis (NF) is a multisystem genetic disorder that commonly is associated with cutaneous, neurological, and orthopedic manifestations. It is the most frequent of the so-called hamartoses.
Contents:- Introduction Clinical Differentials Workup Treatment Medication Follow-up Miscellaneous Pictures Bibliography

Neurofibromatosis type 1 aka/or von Recklinghausen's disease may cause or feature Carcinogenesis Lung cavity Orbital mass Phakomatosis Sakurai-Lisch nodule Symptoms and Signs Café au lait spots Cutaneous nodules Fits Gastrointestinal bleeding Hemihypertrophy Horner's syndrome Hypertension, systemic Kyphosis Megencephaly Neurofibromata Pectus excavatum Peripheral neuropathy Precocious puberty Retinal pathology Scoliosis Subcutaneous nodules Cardiac and vascular conditions Renal artery stenosis Hyperplastic conditions Hamartomatosis Psychiatric conditions Learning disability Trauma, mechanical and physical conditions Bowel obstruction may be a risk factor for Congenital conditions Neural tube defects Neoplastic conditions Astrocytoma Ependymoma Meningioma Phaeochromocytoma Malignant neoplastic...

Journal of Pediatric Orthopaedics. 26(3):413-423, May/June 2006. Crawford, Alvin H. MD; Schorry, Elizabeth K. MD
Abstract - Type 1 neurofibromatosis (NF-1), also known as von Recklinghausen disease, is one of the most common human singlegene disorders, affecting at least 1 million persons throughout the world. It encompasses a spectrum of multifacted...