Radiology Cases Pagets Disease of Bone LSBU

Description: Paget's disease is a disease of bone, which develops disordered architecture and is found more commonly in the elderly and in males. The mechanism for this pathology is unknown. Under the microscope, the disease shows disorder of the basic structural unit, normally an arrangement of concentric Haversian Systems. Radiographically, this is reflected in the loss of normal distinction between cortex and medulla of bone. The trabecular detail is lost or blurred. The disease process frequently starts as an area of low bone density, adjacent to a joint or apophysis.