osteomalacia CHORUS

Description: insufficient mineralization of osteoid
etiology:
* dietary deficiency of vitamin D3, lack of solar irradiation
* deficiency of metabolism of vitamin D
o chronic renal tubular disease
o phenobarbitol, diphenylhydantoin
* decreased absorption of vitamin D (malabsorption, gastrectomy)
* diphosphonates (decrease calcium deposition; rx. for Paget's)
findings:
* osteopenia
* bone softening/deformity: hourglass thorax, bowing of long bones
* increased fractures, biconcave vertebral bodies
* mottled skull
* pseudofractures