Inhibition of Staphylococcus epidermidis biofilms using polymerizable vancomycin derivatives CORR Open Access

Description: Clinical Relevance The approaches presented here may offer new strategies for developing biofilm-resistant orthopaedic materials. Specifically, polymerizable derivatives of traditional antibiotics may allow for direct polymerization into existing materials such as PMMA bone cement while minimizing mechanical property compromise. Questions remain regarding ideal monomer structure(s) that confer biologic and mechanical benefits.
Inhibition of Staphylococcus epidermidis biofilms using polymerizable vancomycin derivatives. Lawson MC, Hoth KC, Deforest CA, Bowman CN, Anseth KS. Clin Orthop Relat Res. 2010 Aug;468(8):2081-91. (full text)