2010 Histological features of pseudotumor-like tissues from metal-on-metal hips CORR Open Access

Description: Conclusions Pseudotumor-like reactions can be caused by high wear, but may also occur around implants with low wear, likely because of a metal hypersensitivity reaction. Histologic features including synovial integrity, inflammatory cell infiltrates, tissue organization, and metal particles may help differentiate these causes.
Clinical Relevance Painful hips with periprosthetic masses may be caused by high wear, but if this can be ruled out, metal hypersensitivity should be considered.
Histological features of pseudotumor-like tissues from metal-on-metal hips. Campbell P, Ebramzadeh E, Nelson S, Takamura K, De Smet K, Amstutz HC. Clin Orthop Relat Res. 2010 Sep;468(9):2321-7. (full text)