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Different T cell subsets in the nodule and synovial membrane

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Location: http://www3.interscience.wiley.com/cgi-bin/fulltext/119755360/PDFSTART

Description: CONCLUSION: IL-17 family members are varyingly expressed in rheumatoid nodules. The paucity of IL-17A in nodules suggests an important difference from that observed in the synovium. The expression of IL-23 below a critical threshold level seems the most likely explanation for the virtual absence of IL-17A. The presence of tissue destruction within the nodule despite the absence of IL-17A suggests that IL-17A may be an important amplifier rather than an absolute requirement for inflammation in RA.
Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules. Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA. Arthritis Rheum. 2008 Jun;58(6):1601-8

Type: Reference Material
Author/Contact: Stamp et al
Institution: Arthritis Rheum.
Primary Subject/Category:

Language: English

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Added: Fri Nov 13 2009