Diagnosis and Management of Liposarcoma

Description: Medscape The differential diagnosis of a soft-tissue mass includes a variety of benign lesions as well as sarcoma, primary or metastatic carcinoma, melanoma, and lymphoma. There is no distinctive, classic presentation for extremity sarcoma, and chief complaints may vary. It is important to consider the etiology of the neoplasm and any predisposing factors elicited by a careful history. Factors increasing suspicion for sarcoma diagnosis include genetic predisposition syndromes (Li-Fraumeni syndrome, neurofibromatosis), radiation exposure, chronic lymphedema (Stewart-Treves syndrome), trauma, or certain chemical occupational exposures