Transformation- CREST syndrome with scleroderma telangiectasias and subcutaneous calcification

Description: Scleroderma is a systemic disease, but commonly affects the hands in several ways. Finger stiffness is typical. Scleroderma may be associated with other syndromes, and a common combination is Calcinosis, Raynaud's, Esophageal motility disorders, Scleroderma and Telangiectasias - CREST syndrome. In this syndrome, the hands are affected by calcinosis, Raynaud's and scleroderma. Skin ulcerations may arise from Raynaud's related peripheral vascular insufficiency (fingertips), from scleroderma related skin tightness (extensor surfaces of the proximal interphalangeal or metacarpophalangeal joints), or from extrusion of subcutaneous calcium formations (any location).