Orthopedics > OCOSH Classification > Orthopaedic Procedures > Bone Transplantation > 2011 Healing of Long-term Frozen Orthotopic Bone Allografts is not Affected by MHC Differences Between Donor and Recipient CORR Open Access

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2011 Healing of Long-term Frozen Orthotopic Bone Allografts is not Affected by MHC Differences Between Donor and Recipient CORR Open Access

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Location: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069278

Description: It remains unclear whether differences in the major histocompatibility complex (MHC) influence incorporation of bone allografts and their subsequent biologic performance. Results We detected no alloantibody production to graft MHC-I antigens, and found no differences between syngeneic and MHC mismatched grafts in terms of remodeling with host bone, graft healing, and mechanical strength.
Conclusions Mismatches for MHC antigens do not seem to play a decisive role in healing of long-term, deep-frozen bone allografts.
Healing of Long-term Frozen Orthotopic Bone Allografts is not Affected by MHC Differences Between Donor and Recipient. Reikerås O, Reinholt FP, Zinöcker S, Shegarfi H, Rolstad B. Clin Orthop Relat Res. 2011 May;469(5):1479-86 (full text)

Type: Reference Material
Author/Contact: Reikerås et al
Institution: CORR
Primary Subject/Category:

Language: English

Submitted by: admin
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Added: Wed May 04 2011