Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis

Description: Questions/purposes We therefore asked (1) whether macrophages associated with polyethylene particle-induced chronic inflammation are recruited locally or systemically and (2) whether the recruited macrophages are associated with enhanced osteolysis locally.
Conclusions Infusion of clinically relevant polyethylene particles, similar to the human scenario, stimulated systemic migration of remotely injected macrophages and local net bone resorption.
Continuous Infusion of UHMWPE Particles Induces Increased Bone Macrophages and Osteolysis Pei-Gen Ren, Afraaz Irani, Zhinong Huang, Ting Ma, Sandip Biswal & Stuart B. Goodman