A prospective randomized double-blinded single-site control study comparing blood loss prevention of tranexamic acid to epsilon aminocaproic acid for corrective spinal surgery BMC Surgery

Description: Trial proposal with literature review. Not a report of the research results.
Discussion The primary goal of the study is to determine perioperative blood loss as a measure of the efficacy of TXA, EACA, and placebo. Based on current literature and the mechanism by which the medications act, we hypothesize that TXA will be more effective at reducing blood loss than EACA or placebo and result in improved patient outcomes.
A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery Kushagra Verma , Thomas J Errico , Kenneth M Vaz and Baron S Lonner BMC Surgery 2010, 10:13 Full text available