Colchicine in acute gouty arthritis

Description: Despite the fact that there is perhaps only one double blind placebo controlled study on colchicine in acute gout where gastrointestinal side effects occurred before the relief of pain [1], and the optimal dose of colchicine still remains elusive, there has not been any significant change to the recommended dosage in acute gout nearly half a century later [1].
Colchicine in acute gouty arthritis: the optimum dose? Varughese GI, Varghese AI. Arthritis Res Ther. 2006;8(5):405.