Pseudogout attack associated with chronic thyroiditis and Sjögren's syndrome

Description: A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjögren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjögren's syndrome has not been previously reported.
Pseudogout attack associated with chronic thyroiditis and Sjögren's syndrome. Hama Y, Mineshita M, Kondo T, Yasuda H, Arai S, Warabi H. Intern Med. 1999 Jan;38(1):59-62. full text