The role and clinical implications of G6PI in experimental models of rheumatoid arthritis

Description: Recently it was shown that G6PI immunization induces severe symmetrical peripheral polyarthritis in genetically unaltered DBA/I mice. In that model CD4+ T cells are necessary not only for the induction but also for the effector phase of arthritis. Here we review the pathomechanisms that lead from systemic autoreactivity to arthritis in these models, consider the relevance of anti-G6PI immune reactivity for RA, and discuss the insights into the pathogenesis of RA and possibly other autoimmune conditions that can be gained from these models.
The role and clinical implications of G6PI in experimental models of rheumatoid arthritis. Kamradt T, Schubert D. Arthritis Res Ther. 2005;7(1):20-8