Orthopedics > OCOSH Classification > Orthopaedic Procedures > Arthroplasty > Replacement Arthroplasty > Knee Replacement Arthroplasty > Determination of the efficacy and side-effect profile of lower doses of intrathecal morphine in patients undergoing total knee arthroplasty

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Determination of the efficacy and side-effect profile of lower doses of intrathecal morphine in patients undergoing total knee arthroplasty

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Location: http://www.biomedcentral.com/1471-2253/8/5/abstract

Description: Intrathecal (IT) morphine provides excellent post-operative analgesia, but causes multiple side effects including nausea and vomiting (PONV), pruritus and respiratory depression, particularly at higher doses. The lowest effective dose of spinal morphine in patients undergoing total knee arthroplasty is not known.
We evaluated the analgesic efficacy and side effect profile of 100 - 300mcg IT morphine in patients undergoing elective total knee replacement in this prospective, randomized, controlled, double-blind study.
Both 200mcg and 300mcg provided comparable postoperative analgesia, which was superior to that provided by 100mcg IT morphine in patients undergoing total knee arthroplasty. Based on these findings, we recommend that 200mcg IT morphine be used in these patients.
Patrick Hassett , Bilal Ansari , Pachaimuthu Gnanamoorthy , Brian Kinirons and John G Laffey BMC Anesthesiology 2008, 8:5 Full text available

Type: Reference Material
Author/Contact: Hassett et al
Institution: BMC Anesthesiology
Primary Subject/Category:

Language: English

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Added: Sat Sep 27 2008