Herpetic Whitlow eMedicine Emergency

Description: Herpetic whitlow is an intense painful infection of the hand involving 1 or more fingers that typically affects the terminal phalanx. Herpes simplex virus 1 (HSV-1) is the cause in approximately 60% of cases of herpetic whitlow, and herpes simplex virus 2 (HSV-2) is the cause in the remaining 40%.
Adamson first described herpetic whitlow in 1909, and in 1959, it was noted to be an occupational risk among health care workers.
As in other mucocutaneous herpetic infections, herpetic whitlow is initiated by viral inoculation of the host through exposure to infected body fluids via a break in the skin, most commonly a torn cuticle. The virus then invades the cells of the dermis and subcutaneous tissue, and clinical infection ensues within a matter of days.
Author: Michael S Omori, MD, 2007