1998 Idiopathic scoliosis in twins studied by DNA fingerprinting

Description: J Bone Joint Surg Br. 1998 Mar;80(2):212-7. Idiopathic scoliosis in twins studied by DNA fingerprinting: the incidence and type of scoliosis.Inoue M, Minami S, Kitahara H, Otsuka Y, Nakata Y, Takaso M, Moriya H. Department of Clinical Radiology, School of Medicine, Chiba University and Chiba Higashi Hospital, Japan. We investigated 21 pairs of twins for zygosity and idiopathic scoliosis. DNA fingerprinting confirmed that 13 pairs were monozygotic and eight were dizygotic. There was concordance for idiopathic scoliosis in 92.3% of monozygotic and 62.5% of dizygotic twins. Of the 12 pairs of monozygotic twins concordant for idiopathic scoliosis, six showed discordant curve patterns but eight had differences in Cobb angle of less than 10 degrees. Seven of the ten pairs of monozygotic twins had similar back shapes. Our findings suggest that there is a genetic factor in the aetiology of idiopathic scoliosis; they also indicate that there is a genetic factor in both the severity of the curve and the general shape of the back.