Pseudohypoparathyroidsim Wheeless

Description: Discussion: - lack of responsiveness to PTH due to defect in adenyl cyclase; - clinical picture may resemble of hypoparathyroidism; - due to inability of bone & kidney to respond to parathyroid hormone, hypocalcemia and hyperphosphatemia occur in spite of elevated parathyroid levels; - pts w/ this disorder have a characteristic clinical appearance that includes short stature, round facies, & shortened 4th metacarpals; - subQ calcifications that may be present in pseudohypoparathyroidism not present in the idiopathic disorder;