Non-Ossifying Fibroma Wheeless

Description: Discussion: - also known as fibrous cortical defect; - most common bone lesion (40% children); - it results from defect of periosteal cortical bone development which leads to failure of ossification; - natural history: - lesion typically develops in childhood and adolescence; - during adolescence non ossifying fibroma is an active stage 2 lesion that persists or enlarges throughout childhood. - w/ skeletal maturation, NOF becomes latent & either regresses or ultimately ossifies; - when tumor occupies> 50% of diameter of bone, bone is prone to frx;