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Osteogenesis Imperfecta NORD

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Location: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Osteogenesis%20Imperfecta

Description: Synonyms of Osteogenesis Imperfecta Brittle Bone Disease Ekman-Lobstein Disease Lobstein Disease (Type I) OI Vrolik Disease (Type II) Disorder Subdivisions Osteogenesis Imperfecta Type I Osteogenesis Imperfecta Type II Osteogenesis Imperfecta Type III Osteogenesis Imperfecta Type IV General Discussion Osteogenesis imperfecta (OI) is a group of rare disorders affecting the connective tissue and characterized by extremely fragile bones that break or fracture easily (brittle bones), often without apparent cause. The specific symptoms and physical findings associated with OI vary greatly from case to case. The severity of OI also varies greatly, even among individuals of the same family. OI may be a mild disorder or may result in severe complications. Four main types of OI have been identified. OI type I is the most common and the mildest form of the disorder. OI type II is the most severe. In most cases, the various forms of osteogenesis imperfecta are inherited as autosomal dominant traits. .

Type: Reference Material
Author/Contact: Not available
Institution: NORD
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Language: English

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Added: Sun Dec 10 2006