Multiple Hereditory Exostosis Diseases Database

Description: Multiple hereditary exostoses aka/or Multiple cartilaginous exostoses, type 1 Definitions Hereditary Multiple Exostoses: "Hereditary disorder transmitted by an autosomal dominant gene and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation." Source: Medical Subject Headings, 2007_2006_08_08 "Hereditary disorder transmitted by autosomal dominant genes (EXT1-3) and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones. The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence. The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation." Source: National Cancer Institute Thesaurus, 2006_03D may cause or feature Symptoms and Signs Exostoses X-ray abnormalities Exostoses may be a risk factor for Chondrosarcoma belong(s) to the category of Autosomal dominant conditions