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Muscle Cramp
[OCOSH Code: D009120 55300003 R25.2 MD_MC]

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Cramps PatientPlus

Location: http://www.patient.co.uk/showdoc/40000075/

Cramp usually means " a spasmodic, painful, involuntary, contraction of skeletal muscle."1 and there are many causes. This transient, involuntary episode of pain, is usually sustained for minutes and even up to 10 minutes, and whole muscles or muscle groups go into spasm. The lower limbs are almost invariably involved.
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Familial Muscle Cramps OMIM

Location: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=158400

Van den Berghe et al. (1980) described a kindred with generalized muscle cramps inherited as an autosomal dominant, with maximal expression during adolescence. The age of onset varied from age 10 to 15 years. Muscle enzymes were elevated with a peak level between 15 and 25 years. The complaints seemed...
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Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people

Location: http://www.bmj.com/cgi/content/abstract/310/6971/13?ijKey=4cd9c780f088ef4e3f6207b706c113eeba395ec0&k ...

The results indicate that quinine can prevent nocturnal leg cramps in general ambulatory populations. Given the possible serious side effects of treatment with quinine, the benefits and risks in patients taking this drug should be closely monitored.
Man-Son-Hing M, Wells G BMJ 1995;310:13-6.
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Muscle Cramps

Location: http://archinte.ama-assn.org/cgi/content/abstract/150/3/511?ijKey=8996a49280f88a53356933c19ba5ac05d4 ...

Painful involuntary skeletal muscle contractions, or cramps, are common patient complaints and may be classified as examples of true cramp, tetany, contracture, or dystonia. The pathophysiologic and clinical features of each of these diagnoses are described. The approach to the patient with cramps should emphasize the history, physical examination, and,...
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Nocturnal Leg Cramps in older people PMJ

Location: http://pmj.bmj.com/cgi/content/full/78/924/596

Nocturnal leg cramps are common in older people. Such cramps are associated with many common diseases and medications. Physiological methods may be useful for preventing cramps in some people, but there have been no controlled trials of these approaches. Quinine is moderately effective in preventing nocturnal leg cramps. However, there...
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Prescribing of quinine and cramp inducing drugs in general practice BMJ

Location: http://www.bmj.com/cgi/content/full/311/7019/1541?view=long&pmid=8520397

Our study highlighted that most patients prescribed quinine may have had another pharmacological cause for their leg cramps. A review of the need for and dosage of current drugs may be all that is required to alleviate the problem. Controversy surrounds the efficacy of quinine in the treatment of nocturnal leg...
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