Pigmented Villonodular Synovitis (Subscribe)  

AJR 2003; 181:761-769 Hypointense Synovial Lesions on T2-Weighted Images: Differential Diagnosis with Pathologic Correlation José A. Narváez, Javier Narváez, Raúl Ortega1, Eugenia De Lama1, Yolanda Roca1 and Noemí Vidal
Synovial tissue that lines joint cavities, bursae, and tendinous sheaths is generally too thin to be shown on MRI. However, as synovial tissue thickens...

CONCLUSION: These findings suggest that periarticular bone resorption and cartilage destruction which characterize PVNS may be related to the expression of inflammatory cytokines, which in turn stimulate MMP production.
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. O'Keefe RJ, Rosier RN, Teot LA, Stewart JM,...

We followed up seven patients with histologically confirmed diffuse pigmented villonodular synovitis in a prospective study between 1992 ans 2001. The mean age at diagnosis was 30.7 years. The patients underwent synovectomy, followed by radiotherapy with a total dose of 35 Gy in 20 fractions. In all cases, the excision...

A previously well 30 year old man presented with a short history of intra-articular mechanical locking, swelling, and anteromedial joint line pain. There was localised tenderness, and McMurray’s test was positive. Arthroscopy revealed a 3.6 ´ 2.6 ´ 1.5 cm firm pedicular localised pigmented villonodular synovitis originating from the insertion...

Conclusions. We therefore suggest that pigmented villonodular synovitis of the knee joint should be classified more strictly than before into a potentially neoplastic (diffuse) form and a reactive granulomatous (local) form. From the cases observed, we conclude that degenerative joint lesions may be the cause of the reactive granulomatous form.
Localized...

Pigmented villonodular synovitis is a rare benign disorder and usually affects young and middle-aged adults. It occurs either as a localised pedunculated form or more common diffuse form, and is almost always unifocal. Only few cases of multifocal involvement have been reported, all of them in children. Multifocal pigmented villonodular...

Pigmented villonodular synovitis (PVNS) is most often a monoarticular disease affecting patients in their third or fourth decade. The knee joint is most commonly affected and due to the large recesses in the knee, patients often present late after the disease has insidiously spread to extraarticular sites around the knee....

# monoarthritis
# young adults
# benign neoplasm affecting extremity joints
# subchondral erosions on BOTH sides of joint (!)
# hemosiderin deposited in synovium (with characteristic low signal on MR)
# articular cartilage preserved (despite extensive marginal erosions; similar to gout)
# NO calcification, but soft tissue may appear dense on X-ray/CT

Pigmented villonodular synovitis is a proliferative disorder of the synovium. The knee and upper extremity are the most commonly involved areas. Complete excision is the treatment of choice in most cases. Pigmented villonodular synovitis involving the subtalar joint is extremely uncommon, and has been rarely reported in the English literature
Pigmented...

Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of uncertain etiology that affects synovial lined joints, bursae, and tendon sheaths. The disorder results in various degrees of villous and/or nodular changes in the affected structures. Two primary forms are described, including a diffuse form that affects the entire synovial...

Pigmented villonodular synovitis (PVNS) is a proliferation of the syn- ovium that leads to villous or nodular changes of synovial-lined joints, bursae and tendon sheaths.1 It is rare and likely caused by either an inflammatory response or neoplastic formation of the synovium. Both the extra- and the intra-articular types appear...

We report six children with pigmented villonodular synovitis. They ranged in age from seven to fifteen years. In four patients, the knee was involved. One patient had involvement of the ankle, and one had diffuse involvement along a metacarpal. In five cases, the diagnosis was not suspected clinically or radiographically,...

Pigmented villonodular synovitis of the elbow is rare and even rarer in children. We report a case of pigmented villonodular synovitis of the elbow in a 6-year-old girl who underwent total synovectomy after the diagnosis was confirmed by biopsy. The osteochondral defect at the olecranon was filled with calcium phosphate...

Pigmented villonodular synovitis is an uncommon disease that remains a diagnostic challenge. Presenting complaints commonly involve one joint, most often the knee or hip. Symptoms of pain and swelling characteristically have an insidious onset and are slowly progressive. The physical examination may be completely normal. Radiographs of the knee may...

Pigmented villonodular synovitis is a rare and benign but potentially locally aggressive disease that should be considered in younger patients who present with monoarticular joint symptoms and pathology. We present a 30-year-old Sudanese woman with a huge mass arising from the right hip joint. A multimodality radiological approach to investigation...