Orthopedics > OCOSH Classification > Bone Diseases > Eosinophilic Granuloma

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Internet resources relating to monostotic and polyostotic histiocytosis.
[OCOSH Code: D004803 238476000 D76.0 BD_EG]

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eosinophilic granuloma

Location: http://chorus.rad.mcw.edu/doc/00142.html

# 60-80% of histiocytosis X
# age 5 - 10 yrs
# presentation: bone pain, local swelling, irritability
# bones
* 50 - 75% solitary / monostotic
* skull/mandible (50%): "punched-out" lucencies, "hole within a hole", "button sequestrum", "floating teeth"
* spine/pelvis (25%): vertebra...
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View Details Visit Resource Review It Rate It Bookmark It Added: Thu Jan 31 2002

Eosinophilic Granuloma of the Spine

Location: http://www.wheelessonline.com/ortho/eosinophilic_granuloma_of_the_spine

Wheeless' Textbook of Orthopaedics - Discussion: - most common in the thoracic spine; - may present with progressive back pain; - vertebra plana: - in 2-6 yrs old child, EOG may present w/...
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View Details Visit Resource Review It Rate It Bookmark It Added: Mon Feb 04 2002

Eosinophilic Granuloma POSNA Study Guide

Location: http://www.posna.org/education/StudyGuide/eosinophilicGranuloma.asp

Objectives Discuss the relationship and/ or nomenclature of eosinophilic granuloma, Letterer-Siwe disease, Hand-Schuller-Christian disease, histiocytosis X, and Langerhans-cell granulomatosis Discuss the bones most frequently affected by eosinophilic granuloma Discuss treatment of spine lesions (vertebra plana) associated with eosinophilic granuloma
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View Details Visit Resource Review It Rate It Bookmark It Added: Sat Mar 24 2007

Eosinophilic Granuloma Wheeless

Location: http://www.wheelessonline.com/ortho/eosinophilic_granuloma

Discussion: - includes a group of disorders characterized by a variety of tumor like lesions, which arise from from clonal proliferation of Langerhans-type histiocytes; - most common in children less than 12...
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Hand-Schueller-Christian disease

Location: http://chorus.rad.mcw.edu/doc/00182.html

chronic diseminated form of histiocytosis X
* age 1 - 3 yrs most common
* skull and mandible lesions similar to EG, but more numerous
* "geographic skull", "floating teeth"
* adenopathy
* enlarged liver and spleen
* skin lesions
* diabetes insipidus
* exophthalmos
* lung disease
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View Details Visit Resource Review It Rate It Bookmark It Added: Thu Jan 31 2002

Histiocytosis X Disease Database

Location: http://www.diseasesdatabase.com/ddb5906.htm

6 synonyms or equivalents were found. Histiocytosis X aka/or Langerhans cell histiocytosis aka/or Letterer-Siwe syndrome aka/or Schueller-Christian disease aka/or Eosinophilic granuloma aka/or Hand-Schuller-Christian disease may cause or feature Miscellaneous syndromes Bone cyst Bone lysis Hepatocellular jaundice Orbital mass Symptoms and Signs Breathlessness Exophthalmos Gum pathology Haemoptysis Hepatomegaly Lymphadenopathy Mastoiditis Oral ulceration Platyspondyly Rash Short stature Splenomegaly Suppurative otitis media Tooth loss Haematological abnormalities Leucoerythroblastic anaemia Neutropenia Red cell production reduced Thrombocytopenia Biochemical abnormalities Diabetes insipidus, non-nephrogenic Hepatocellular jaundice Histopathological abnormalities Pulmonary fibrosis X-ray abnormalities Periosteal reaction Endocrine conditions Hypopituitarism Malignant neoplastic conditions Bone metastases Respiratory conditions Pneumothorax Pulmonary fibrosis Histiocytosis X:...
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View Details Visit Resource Review It Rate It Bookmark It Added: Sat Mar 24 2007

Langerhans Cell Histiocytosis OMIM

Location: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604856

The Langerhans cell is a dendritic cell of the epidermis that was first described by a medical student, Paul Langerhans, who thought it was part of the nervous system (Langerhans, 1868). Birbeck et al. (1961) found that the Langerhans cell displays a unique electron-microscopic morphology. The discoveries that these cells...
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Letterer-Siwe disease

Location: http://chorus.rad.mcw.edu/doc/00230.html

Acute diseminated form of histiocytosis X
* age 0 - 1 yr
* worst prognosis (70% mortality)
* visceral involvement: hepatosplenomegaly
* purpura, anemia, lymphadenopathy
* bone: extensive lytic skull lesions, "raindrop" skull
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View Details Visit Resource Review It Rate It Bookmark It Added: Thu Jan 31 2002

multicentric reticulohistiocytosis CHORUS

Location: http://chorus.rad.mcw.edu/doc/00278.html


# females, middle age
# deposition arthropathy
# bilaterally symmetric involvement of hands
# soft-tissue swelling
# well-circumscribed marginal bony erosions
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View Details Visit Resource Review It Rate It Bookmark It Added: Thu Jan 31 2002