Orthopedics > OCOSH Classification > Orthopaedic Procedures > Ligament Reconstruction > 2009 Graft healing in anterior cruciate ligament reconstruction

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2009 Graft healing in anterior cruciate ligament reconstruction

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Location: http://www.smarttjournal.com/content/1/1/21

Description: Successful anterior cruciate ligament reconstruction with a tendon graft necessitates solid healing of the tendon graft in the bone tunnel. Improvement of graft healing to bone is crucial for facilitating an early and aggressive rehabilitation and ensuring rapid return to pre-injury levels activity. Tendon graft healing in a bone tunnel requires bone ingrowth into the tendon. Indirect Sharpey fiber formation and direct fibrocartilage fixation confer different anchorage strength and interface properties at the tendon-bone interface. For enhancing tendon graft-to-bone healing, we introduce a strategy that includes the use of periosteum, hydrogel supplemented with periosteal progenitor cells and bone morphogenetic protein-2, and a periosteal progenitor cell sheet. Future studies include the use of cytokines, gene therapy, stem cells, platelet-rich plasma, and mechanical stress for tendon-to-bone healing. These strategies are currently under investigation, and will be applied in the clinical setting in the near future.
Chih-Hwa Chen Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology 2009, 1:21 Full text available

Type: Reference Material
Author/Contact: Chih-Hwa Chen
Institution: Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology
Primary Subject/Category:

Language: English

Submitted by: admin
Hits: 393
Added: Sun Sep 27 2009
Last Modified: Wed May 11 2011