Unilateral bifid femur with monodactylous ectrodactyly OMIM

Description: %228250 FEMUR, UNILATERAL BIFID, WITH MONODACTYLOUS ECTRODACTYLY
Alternative titles;
GOLLOP-WOLFGANG COMPLEX; GWC
Gollop et al. (1980) described 2 brothers, each with 1 normal upper limb; 1 had tridactylous ectrodactyly of 1 hand with normal radius and ulna, and the other had monodactyly of 1 hand with absent ulna. Both had monodactyly of the feet, absence of the tibias, and unilateral bifurcation of the femur. A sister of the paternal grandfather was purportedly similarly affected. The mode of inheritance was considered unclear. Kohn et al. (1989) reported 2 unrelated families, each with 2 affected offspring with bifid femur, absent tibia, and ectrodactyly. In each family, the healthy parents were consanguineous.