OWL: OCOSH Classification/Bone Diseases/Orthopaedic Oncology/Connective and Soft Tissue Neoplasms/Bone Neoplasms/Ewings Sarcoma

Ewing Family of Tumors PDQ

Not Available — 2007-07-10 17:14:46 GMT

Ewing Family of Tumors (PDQ�): Treatment
This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, staging, and treatment of the Ewing family of tumors (EFT). In this review, the EFT includes bone primaries (classic Ewing sarcoma, primitive neuroectodermal tumor, and Askin tumor [chest wall]), which will be referred to as Ewing tumor of bone (ETB) and extraosseous primaries, which will be referred to as extraosseous Ewing sarcoma (EOE).

Ewings Sarcoma Doctors Doctor

Not Available — 2007-07-07 17:14:46 GMT

Ewing's sarcoma is a sarcoma of the bone classically described under small round blue cell tumors (SRBCT). There is considerable clinical and histologic overlap between this tumor and the primitive neuroectodermal tumor (PNET). For many years, pathologists struggled to make a diagnostic distinction. Now with sophisticated molecular biological analysis, it turns out that both tumors share a common and unique chromosomal translocation. Most investigators now believe that Ewing's sarcoma and PNET are different morphological expressions of one tumor type.

Ewings Sarcoma SA Registrars Notebook

Not Available — 2007-07-06 17:14:46 GMT

Brief Notes - Incidence, Clinical, Xrays, Pathology, Investigation, Differential Diagnosis, Treatment, Prognosis

Ewings Sarcoma Wheeless

Wheeless — 2007-03-28 17:14:46 GMT

Discussion: - prevalence: - it represents approx 7% of all primary bone malignancies; - Ewing's sarcoma is more common in males and is rare in blacks; - source: - uncertain origin; - may arise from primitive reticulum cells of marrow; - common karyotypic translocation between chromosomes 11 and 22; - age: - it is a tumor of children & young adults, w/ most cases occurring between ages of 10 and 20 years; - 3% of Ewing's sarcoma occurs in children less than 3 years of age; - 64% of Ewing's sarcoma occur in the second decade; - genetics: - expresses p30/32 MIC2 antigen (cell surface glycoprotein); - 85% contain chromosomal translocation at the t(11;22)(q24;q12); - prognosis: - potentially the most lethal of all the bone tumors; - most important adverse prognostic factor was metastatic disease detectable at the time of diagnosis; - it almost always presents as a stage IIb lesion; - before routine use of adjuvant chemo, pts w/ Ewing's were treated w/ XRT alone, & 5 year survival rate was no more than 15%; - w/ use of adjuvant chemo, 5 year survival rate to more than 60%; - w/ non metastatic Ewing's, disease free survival is 55-70% versus 22-33% for metastatic; - pts require careful follow-up, due to post-XRT osteosarcoma

Ewings Sarcoma Wikibooks

Collaborative — 2006-12-02 17:14:46 GMT

Ewing's sarcoma is a malignant tumor that belongs to a broader family of tumors that includes PNET (primitive neuroectodermal tumors). In simple terms, these tumors are all pathologically characterized by the so-called "small round blue cells." Ewing's sarcoma almost always occurs in bone, although other members of the PNET family can occur anywhere. Ewing's is pathologically differentiated from other members of the family on the basis of immunohistochemical staining. Ewing's sarcoma was described by James Ewing in 1920. Similar tumors were reported earlier than this, but it was the work of Ewing which established that the disease was separate from lymphoma or neuroblastoma. Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Ewing sarcoma From Wikibooks, the open-content textbooks collection

Ewings Tumor Pre-Test and Tutorial

Frassica & Sim — 2007-03-27 17:14:46 GMT

Ewing's Tumor Pre-test and tutorial Frank J. Frassica, MD Professor of Orthopaedics & Oncology Johns Hopkins University Department of Orthopaedic Surgery Baltimore, Maryland Franklin H. Sim, MD Chief, Section of Orthopedic Oncology Mayo Clinic Rochester, Minnesota Section of Orthopedics Hyperguide

Primitive Neuroectodermal Tumor Doctors Doctor

Not Available — 2007-07-07 17:14:46 GMT

Primitive Neuroectodermal Tumor (PNET) is a soft tissue sarcoma classically described under small round blue cell tumors (SRBCT). There is considerable clinical and histologic overlap between this tumor and Ewing's sarcoma (ES). For many years, pathologists struggled to make a diagnostic distinction. Now with sophisticated molecular biological analysis, it turns out that both tumors share a common and unique chromosomal translocation. Most investigators now believe that Ewing's sarcoma and PNET are different morphological expressions of one tumor type. In general, Ewing's sarcoma arises within the bone while PNET arises within soft tissues. However, there are overlap cases of Ewing's sarcoma arising within soft tissue (Extraosseous Ewing's Sarcoma) and PNET arising within the bone. Under the microscope, the tumors share a considerable homology though there are usually more neuroendocrine features with PNET. Ewing's sarcoma is thought to be a more undifferentiated tumor. Though data is conflicting, some investigators believe ES to have a slightly better prognosis. PNETs most commonly occur in buttocks and upper thighs and may be intimately associated with a large peripheral nerve such as the sciatic nerve.

Small round blue cell sarcoma of bone mimicking atypical Ewings sarcoma

Llombart-Bosch — 2007-07-07 17:14:46 GMT

Small round blue cell sarcoma of bone mimicking atypical Ewing's sarcoma with neuroectodermal features. An analysis of five cases with immunohistochemical and electron microscopic support
Antonio Llombart-Bosch, MD 1 *, Marie Jos� Lacombe, MD 2, Genevieve Contesso, MD 2, Amando Peydro-Olaya, MD 1 1Department of Pathology, University of Valencia Medical School, Hospital Clinico Universitario, Valencia, Spain 2Laboratory of Histopathology C, Institute Gustave Roussy, Villejuif, Francebr> Cancer: Volume 60, Issue 7 , Pages 1570 - 1582 Published Online: 28 Jun 2006
Abstract - Of a group of 39 cases of ES, reviewed with electron microscopic study, the authors have isolated five atypical Ewing's Sarcoma (ES), which historically also possessed neuroectodermic traces. These tumors were composed of small round blue cells with rosette-like figures and cytoplasmic glycogen.

Small Round Blue Cell Tumors Doctors Doctor

Not Available — 2007-07-07 17:14:46 GMT

This is a descriptive category describing a large number of malignant tumors that tend to occur in childhood. They are united by having a similar histologic appearance, that is, small round blue cells. Subtle clues may be present to distinguish between the tumors. The pathologist is assisted by immunohistochemistry, electron microscopy, and molecular analysis for chromosomal abnormalities. A list of the most common tumors placed in this category is found below.
Desmoplastic small round blue cell tumor
Ewing's Sarcoma
Leukemia, Acute
Mesothelioma, small cell
Neuroblastoma
Primitive neuroectodermal tumor
Rhabdomyosarcoma
Wilm's tumor

Ewing sarcoma

2002-01-31 17:14:46 GMT

Ewing sarcoma

Ewing's Tumor

2002-02-04 17:14:46 GMT

marrow lesion menu

Ewings tumour

2002-01-31 17:14:46 GMT

Radiology case 4413-3281

Ewings tumour

2002-01-31 17:14:46 GMT

Radiology case 443-3281

Ewings tumour

2002-01-31 17:14:46 GMT

Radiology case 444-3281

Ewings Tumour

2002-01-31 17:14:46 GMT

Radiology case 456-3281