OWL: OCOSH Classification/Bone Diseases/Bone Developmental Diseases/Osteochondrodysplasia/Acquired Hyperostosis Syndrome

Acne Arthritis Case Report

Joan Bathon, M.D. — 2006-11-27 23:05:54 GMT

Our patient's presentation is consistent with the syndrome known as SAPHO (synovitis, acne, pustulosis, hyperostosis and osteomyelitis), and formerly termed acne arthritis. The syndrome is characterized by severe scarring acne and related conditions; hyperostotic bone lesions (particularly in the clavicles and sternum); sacroiliitis; spondylitis; and, peripheral inflammatory arthritis.

Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation

Assmann et al — 2009-09-27 23:05:54 GMT

The acronym SAPHO was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. The etiology of SAPHO syndrome is unknown, an association with infection by semipathogenic bacteria like Propionibacterium acnes has been suggested. We conducted an interventional study of SAPHO patients receiving antibiotics.
Conclusions
For the period of application, the antibiotic therapy seems to have controlled the disease. After antibiotics discontinuation however, disease relapse was observed. SAPHO syndrome thus groups with other chronic inflammatory arthropathies with a need of permanent therapy.
Gunter Assmann , Olaf Kueck , Timm Kirchhoff , Herbert Rosenthal , Jan Voswinkel , Michael Pfreundschuh , Henning Zeidler and Annette D Wagner Arthritis Research & Therapy 2009, 11:R140 Full text available

Google Search for SAPHO Syndrome

Myles Clough — 2006-11-27 23:05:54 GMT

This search was more productive than a search for Acquired Hyperostosis Syndrome but did find a lot of dermatological material

Pubmed Search for Acquired Hyperostosis Syndrome

Myles Clough — 2006-11-27 23:05:54 GMT

Search String "Acquired Hyperostosis Syndrome"[MAJR] URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=%22Acquired+Hyperostosis+Syndrome%22%5BMAJR%5D 111 articles Nov 2006

SAPHO syndrome

Rozin AP — 2009-11-08 23:05:54 GMT

SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy.
SAPHO syndrome: Is a range of pathogen-associated rheumatic diseases extended? Rozin AP Arthritis Research & Therapy 2009, 11:131

SAPHO Syndrome MedicineNet

2006-11-27 23:05:54 GMT

SAPHO Syndrome At A Glance SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. Some researchers feel that the SAPHO syndrome is related to the group of arthritis conditions which typically affect the spine, called the spondyloarthropathies. Treatment of SAPHO syndrome typically involves medications which reduce inflammation.

Sapho Syndrome Orphanet

Prof. Fritz Schilling — 2006-11-27 23:05:54 GMT

Review by Prof. Fritz Schilling Definition - SAPHO syndrome is a disease combining osseaous and articular manifestations associated with skin manifestations. Three diagnostic criteria characterize SAPHO sydrome: 1. multifocal osteitis with or without skin manifestations 2. Sterile acute or chronic joint inflammation associateted with either pustules or psoriasis of thepalms and soles, or acne, or hidradenitis 3. Sterile osteitis in the presence of either psoriasis or acne One of these criteria is sufficient for the diagnosis of SAPHO

SAPHO syndrome treated with pamidronate

Tehrani Rustom — 2006-11-27 23:05:54 GMT

Abstract A middle aged man presented with a 4 year history of painful swelling of both knees and pustular acne on his back. The MRI scan of the knees showed gross synovitis, so did the histopathology of the synovium. A diagnosis of SAPHO syndrome was made and he was treated with IV pamidronate. His pain reduced and acne completely cleared up on therapy. A dermatologist has rarely made a diagnosis of SAPHO syndrome and treated it. Indian Journal of Dermatology Venerology and Leprology 2005

SAPHO Syndrome Wikbooks

Not Available — 2006-12-01 23:05:54 GMT

Definition Synovitis Acne -- commonly involving the face and upper back. Pustulosis -- usually involving the palms of the hands and/or soles of the feet (palmo-plantar pustulosis). Hyperostosis Osteitis SAPHO syndrome is thought to comprise a spectrum of disorders that share some clinical, radiologic and pathologic characteristics. An entity known as chronic recurrent multifocal osteomyelitis (CRMO) was first described in 1972. Subsequently in 1978 several cases of CRMO were associated with clinical findings of palmoplantar pustulosis. Since then, a number of associations between skin conditions and osteoarticular disorders have been reported with a variety of different names including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy. SAPHO was coined in 1987 and basically represents a spectrum of inflammatory osteitis which may or may not be associated with dermatologic pathology. Diagnostic Radiology/Musculoskeletal Imaging/Infection/SAPHO Syndrome From Wikibooks, the open-content textbooks collection

SAPHO Syndrome Wikipedia

Not Available — 2006-11-27 23:05:54 GMT

SAPHO syndrome is thought to comprise a spectrum of disorders that share some clinical, radiologic and pathologic characteristics. An entity known as chronic recurrent multifocal osteomyelitis (CRMO) was first described in 1972. Subsequently in 1978 several cases of CRMO were associated with clinical findings of palmoplantar pustulosis. Since then, a number of associations between skin conditions and osteoarticular disorders have been reported with a variety of different names including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy. SAPHO was coined in 1987 and basically represents a spectrum of inflammatory osteitis which may or may not be associated with dermatologic pathology. Definition Synovitis Acne -- commonly involving the face and upper back. Pustulosis -- usually involving the palms of the hands and/or soles of the feet (palmo-plantar pustulosis). Hyperostosis Osteitis

Synovitis Acne Pustulosis Hyperostosis osteomyelitis syndrome SAPHO

Chris Tehlirain, MD — 2006-11-27 23:05:54 GMT

A gentleman comes in complaining of right knee pain. He is a 48-year-old African American man who was transferred from the Infectious Disease Clinic to the Thayer Medical Service for possible septic arthritis. His symptoms essentially limited his right knee motion; he is not able to flex more than 30 degrees. He has had surgery. There is an area medial to the knee that is swollen, and there is an area lateral to the knee that has been draining pus since August 2005. He has some occasional chills, no fevers, and no other systemic manifestations.