OWL: OCOSH Classification/Trauma/Soft Tissue Injuries

First Aid for Soft Tissue Injuries PatientPlus

Not Available — 2009-05-30 21:06:29 GMT

The term soft tissue injury usually refers to injuries to muscles, ligaments and tendons. It excludes fractures but also more severe injuries such as significant haemorrhage, crush syndrome, head injuries or acute spinal cord compression.
Swift and appropriate action is required to facilitate rapid and complete recovery whilst inappropriate management may be counterproductive.

Stem cells for the treatment of skeletal muscle injury

Quintero et al — 2010-07-07 21:06:29 GMT

Skeletal muscle injuries are extremely common, accounting for up to 35%-55% of all sports injuries and quite possibly affecting all musculoskeletal traumas. These injuries result in the formation of fibrosis, which may lead to the development of painful contractures, increases patients' risk for repeat injuries, and limits their ability to return to a baseline or pre-injury level of function. The development of successful therapies for these injuries must consider the pathophysiology of these musculoskeletal conditions. We discuss the direct use of muscle-derived stem cells and some key cell population dynamics as well as the use of clinically applicable modalities that may enhance the local supply of stem cells to the zone of injury by promoting angiogenesis.
Stem cells for the treatment of skeletal muscle injury. Quintero AJ, Wright VJ, Fu FH, Huard J. Clin Sports Med. 2009 Jan;28(1):1-11. Review. full text

Use of platelet growth factors in treating wounds and soft-tissue injuries

Rozman P, Bolta Z — 2010-07-07 21:06:29 GMT

Tissue repair begins with clot formation and platelet degranulation, which release the growth factors (GFs) necessary for wound repair. Platelet-derived GFs are biologically active substances that enhance tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background of the topical therapy of wounds and soft-tissue injuries with platelet gel (PG) and PG-derived GFs as well as the success of the clinical studies performed so far. Some other interesting topical applications of PG are also described. Platelet-derivatives represent a promising therapeutic modality, offering opportunities for treatment of wounds, ulcers, soft-tissue injuries, and various other applications in regenerative medicine.
Use of platelet growth factors in treating wounds and soft-tissue injuries. Rozman P, Bolta Z. Acta Dermatovenerol Alp Panonica Adriat. 2007 Dec;16(4):156-65.