Caffey disease, or infantile cortical hyperostosis, is a benign, rare, proliferating bone disease affecting infants. Caffey and Silverman first reported this disease as a distinct entity in 1945. Classically, Caffey disease occurs in the early part of the first year of life (<5 mo). It is characterized by a clinical triad...

OTA 2002 - Session 2 Session II - Post-Traumatic Reconstruction Fri., 10/11/02 Post Traumatic Reconstruction, Paper #12, 3:25 PM The Impact of a Dedicated Skeletal Infectious Disease Specialist in the Treatment of Chronic and Post-Traumatic Skeletal Infections Bruce H. Ziran, MD ; N. Rao, MD; Joon Y. Lee, MD; Ronald A....

Last Updated: December 6, 2006
Synonyms and related keywords: ankylosing spondylitis, undifferentiated spondyloarthropathy, Marie-Strümpell disease, von Bechterew disease, von Bechterew's disease, spondyloarthropathies, SpAs, AS, rheumatoid spondylitis, USpA, peripheral enthesitis, sacroiliitis, Schober test, cauda equina syndrome, dactylitis, European Spondyloarthropathy Study Group criteria, Amor criteria, New York criteria, Rome criteria,...

Covers both primary and secondary. Synonyms and related keywords: primary hypertrophic osteoarthropathy, primary HOA, HOA, secondary HOA clubbing, Hippocratic fingers, pachydermoperiostosis, Touraine-Solente-Gole syndrome, Goldbloom's syndrome, Goldbloom syndrome, Pierre Marie-Bamberger's disease, Pierre Marie-Bamberger disease, osteoarthropathie hypertrophiante pneumique, hypertrophic pulmonary osteoarthropathy, HPOA, acropachy, digital clubbing, periostosis, intrathoracic malignancy, intrathoracic infection, cyanotic cardiac...

Synonyms and related keywords: LCPD, Legg-Calvé-Perthes disease, Legg disease, Legg's disease, Legg-Perthes disease, Calvé-Perthes disease, coxa plana, osteochondritis deformans juvenilis, Perthes disease, pseudocoxalgia, quiet hip disease, idiopathic osteonecrosis of capital femoral epiphysis of femoral head, hip pain, groin pain, knee pain, thigh pain, limp, decreased range of motion, painful gait,...

J Bone Joint Surg Br. 1983 May;65(3):299-307
Sarcoma complicating Paget's disease of bone. A clinicopathological study of 62 cases.Schajowicz F, Santini Araujo E, Berenstein M. Out of 21 900 cases filed at the Latin-American Registry of Bone Pathology between April 1940 and July 1981, there were 987 with Paget's disease (4.51 per...

LEGG-CALVE-PERTHES DISEASE Alternative titles; symbols LCPD; LCP LEGG-PERTHES DISEASE PERTHES DISEASE Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and...

Contents - Introduction Differentials Radiograph CT Scan MRI Ultrasound Nuclear Medicine Angiography Intervention Pictures Bibliography
Synonyms and related keywords: Legg-Calvé-Perthes, Legg-Perthes disease, Perthes disease, idiopathic avascular necrosis of the proximal femoral epiphysis, pediatric hip disorder, childhood hip disorder, epiphyseal bone infarction, femoral head infarction, Chandler disease, LPD, LCP, Chandler disease
Legg-Calvé-Perthes...

Definition - Inflammation of bone and cartilage Osteochondritis may be caused by or feature of the following - Miscellaneous syndromes Blount's disease Freiberg's disease Juvenile osteochondrosis of head of femur Juvenile osteochondrosis of spine Kienbock's disease Kohler first disease Sever's disease Sinding Larsen-Johannson disease Orthopaedic conditions Aseptic necrosis of bone Humerus juvenile osteochondritis Iselin's disease Osgood-Schlatter's disease Osteochondritis dissecans may cause or feature - Arthropathy Kyphosis may be a risk...

Paget's disease of bone aka/or Osteitis deformans may cause or feature Miscellaneous syndromes Carcinogenesis Osteoporosis Pathological fracture Symptoms and Signs Angioid streaks Arthropathy Back pain Bone pain Conductive hearing loss Facies abnormality Genu varum Hypertension, systemic Kyphosis Peripheral neuropathy Sabre tibia Sensorineural hearing loss Skull bossing Biochemical abnormalities Acid phosphatase levels raised (plasma or serum) Alkaline phosphatase bone isoenzyme levels raised (plasma or serum) Hypercalciuria X-ray abnormalities Osteosclerosis Cardiac and vascular conditions Cardiac failure, high output Inflammatory conditions Osteitis may be...

Dupuytren contracture, a disease of the palmar fascia, results in the thickening and shortening of fibrous bands in the hands and fingers. This disease entity belongs to the group of fibromatoses that include plantar fibromatosis (Ledderhose disease), penile fibromatosis (Peyronie disease), and fibromatosis of the dorsal proximal interphalangeal (PIP) joints...

Discussion: - includes a group of disorders characterized by a variety of tumor like lesions, which arise from from clonal proliferation of Langerhans-type histiocytes; - most common in children less than 12...

CAMURATI-ENGELMANN DISEASE Alternative titles; CED ENGELMANN DISEASE DIAPHYSEAL DYSPLASIA 1, PROGRESSIVE; DPD1 PROGRESSIVE DIAPHYSEAL DYSPLASIA; PDD Gene map locus 19q13.1 Camurati-Engelmann disease results from domain-specific mutations in the transforming growth factor-beta-1 gene (TGFB1; 190180). Also see Camurati-Engelmann disease type II (606631) in which no mutation in the TGFB1 gene has been found. CLINICAL FEATURES Camurati (1922)...

Contributor: Christopher J Bennett - National Capital Consortium Paget's disease at osseous scintigraphy Factoid 4755 - Created: 2003-04-24 12:50:56-04 - Modified: 2003-05-04 19:15:37-04 ACR Codes: 4.5 Paget’s disease is characterized by high rates of bone turnover and the formation of abnormal, weak bone. It is extremely common, found in...

Attempt to collect cases of this condition. Orthopaedic Rare Conditions Internet Database (ORCID)
Synonyms (MeSH term Essential Osteolysis)
Gorham's Disease
Disappearing Bone Disease
Gorham's Syndrome
Gorham-Stout Syndrome
Idiopathic Massive Osteolysis
Massive Gorham Osteolysis
...

Sickle cell disease (SCD) results from the substitution of a valine residue for glutamic acid at position 6 in the beta-subunit of hemoglobin (Ingram, 1956). With a few minor exceptions, people with only one gene for hemoglobin S (Hb S) are phenotypically normal (sickle trait). People who inherit two Hb...

Gaucher Disease MeSH Classification [C16.320.565.595.554.825.400]
Objectives 1. Describe the pathophysiology of Gaucher's disease 2. Describe the most frequent orthopaedic problems associated with Gaucher's disease 3. Describe radiographic features of Gaucher's disease 4. Discuss the prognosis for Gaucher's disease

Sickle Cell Disease and Related Hemoglobinopathies POSNA Core Curriculum
Objectives
1. Describe different combinations of normal and abnormal hemoglobins and their phenotypic expression
2. Describe the pathophysiology of vasooclusion secondary to hemoglobinopathies
3. Define and describe hand-foot syndrome
4. Describe features of osteomyelitis secondary...

Sickle-cell disease is a general term for a group of genetic disorders caused by sickle hemoglobin (Hgb S or Hb S). In many forms of the disease, the red blood cells change shape, usually looking much like that of a banana, upon deoxygenation because of polymerization of the abnormal sickle... Highly Reputable

Contents - Introduction Clinical Differentials Workup Treatment Medication Follow-up Miscellaneous Pictures Bibliography
Synonyms and related keywords: Sever's disease, calcaneal apophysitis, calcaneal epiphysitis, traction apophysitis, Achilles tendon pain, heel pain
Sever disease is a painful inflammation of the calcaneal apophysis. It is classified with the child and adolescent nonarticular osteochondroses. (The other disease...

Primary lymphoma of bone is an uncommon disease and must be separated from skeletal involvement in systemic lymphoma. The former is stage IE (extranodal, see Staging) disease and may present to the orthopedic surgeon prior to biopsy as a solitary bone lesion simulating a bone sarcoma. The latter, by definition,...

There is no single unifying trait for these disorders. Some have their genetic defect well characterized. Others are still waiting for the discovery of the gene or genes which are damaged. The diagnosis requires careful clinical laboratory evaluation and may require testing for enzymes that are...

Osteogenesis Imperfecta is caused by a mutation in the gene for collagen. The disease is inherited as an autosomal dominant trait, which means persons with one mutation will have the disease and each of their children will have a 50% chance of getting the disease. In about one of five...

Osteoporosis, a chronic progressive disease, is the most common metabolic bone disease in the United States. Osteoporosis can affect almost the entire skeleton. Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility. The disease often...

Although upper extremity vascular disorders are less common than lower extremity disorders, upper extremity vascular disorders affect approximately 10% of the population. Causes of vascular compromise include acute trauma; chronic conditions, such as repetitive microtrauma; and systemic diseases involving metabolic processes, autoimmune processes, or both. General symptoms following vascular compromise...