[Orthopod] Re: osteosarcoma in elderly


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[Orthopod] Re: osteosarcoma in elderly

mylesclough at shaw
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Jan 23, 2008, 12:35 PM

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[Orthopod] Re: osteosarcoma in elderly	Can't Post

As you might expect there is a large literature on osteosarcoma. It
is however, difficult to isolate papers that only deal with the
elderly. The limits function in PubMed is curiously difficult to use.
If you specify Aged (65+) it doesn't exclude all other age groups
unless you do that specifically. So you get a very cumbersome search
string viz -
"Osteosarcoma"[Mesh] NOT Ewing's[All Fields] AND "humans"[MeSH Terms]
AND "aged"[MeSH Terms] NOT (("infant"[MeSH Terms] OR "child"[MeSH
Terms] OR "adolescent"[MeSH Terms]) OR "adult"[MeSH Terms:noexp] OR
"middle aged"[MeSH Terms])

If you copy this search string and paste it into the pubmed search
box you will get 310 returns. 44 of them say they are reviews but as
usual they are mostly "report of a case and review of the literature"
and not really reviews of the whole subject. The same applies to the
full search

I finally decided to look for an article I could read online and look
up references from that. I searched for osteosarcoma elderly in
PubMed Central (PMC) and found
Outcome of patients with osteosarcoma over 40 years of age: Is
angiogenesis a marker of survival?
Eugene TH Ek, Joseline Ojaimi, Yasuyuki Kitagawa, and Peter FM Choong
Int Semin Surg Oncol. 2006; 3: 7. Published online 2006 March 21.
doi: 10.1186/1477-7800-3-7.
PMCID: 1435760
| Abstract | Full Text | PDF–1.8M |

From the reference list of that paper I found

Carsi B, Rock MG. Primary osteosarcoma in adults older than 40 years.
Clin Orthop Relat Res. 2002;397:53–61. doi:
10.1097/00003086-200204000-00008. [PubMed] Related Articles
Grimer RJ, Cannon SR, Taminiau AM, et al. Osteosarcoma over the age
of forty. Eur J Cancer. 2003;39:157–63. doi: 10.1016/S0959-8049(02)
00478-1. [PubMed] Related Articles
Brooks S, Starkie CM, Clarke NM. Osteosarcoma after the fourth
decade. A clinico-pathological review. Arch Orthop Trauma Surg.
1985;104:100–5. doi: 10.1007/BF00454247. [PubMed] Related Articles
Huvos AG. Osteogenic sarcoma of bones and soft tissues in older
persons. A clinicopathologic analysis of 117 patients older than 60
years. Cancer. 1986;57:1442–9. [PubMed] Related Articles
Naka T, Fukuda T, Shinohara N, Iwamoto Y, Sugioka Y, Tsuneyoshi M.
Osteosarcoma versus malignant fibrous histiocytoma of bone in
patients older than 40 years. A clinicopathologic and
immunohistochemical analysis with special reference to malignant
fibrous histiocytoma-like osteosarcoma. Cancer. 1995;76:972–84.
[PubMed] Related Articles
Manoso MW, Healey JH, Boland PJ, Athanasian EA, Maki RG, Huvos AG,
Morris CD.
De novo osteogenic sarcoma in patients older than forty: benefit of
multimodality therapy.
Clin Orthop Relat Res. 2005 Sep;438:110-5. PubMed Related Articles

Then I went back to pubmed to look for related articles on the above
papers. I have added links to related articles to the 5 references
above.
Serendipitously I found an article in Acta Orthopaedica which is open
access. This might have been a better starting point. However, most
of the paper and references focused on chemotherapy.
Bacci G, Ferrari S, Mercuri M, Longhi A, Fabbri N, Galletti S, Forni
C, Balladelli A, Serra M, Picci P.
Free Full Text
Neoadjuvant chemotherapy for osteosarcoma of the extremities in
patients aged 41-60 years: outcome in 34 cases treated with
adriamycin, cisplatinum and ifosfamide between 1984 and 1999.
Acta Orthop. 2007 Jun;78(3):377-84.

There is a large literature on Osteosarcoma and Pagets if that is
relevant to your case.

Myles Clough MD FRCSC
Orthopaedic Surgeon, Retired
Kamloops, BC
mylesclough@shaw.ca
Clinical Instructor, University of British Columbia
Associate Editor, Orthogate www.orthogate.org
Editor, Orthopaedic Web Links (OWL) www.orthopaedicweblinks.com

On 23-Jan-08, at 10:32 AM, Ajmal Yasin wrote:

> I have recently treated an elderly lady of 65 yrs of age with
> primary osteosarcoma of femur. I need to review literature on
> primary osteosarcoma in elderly persons. Please help in finding the
> papers. Thanks
> Dr Ajmal Yasin
> Associate Prof Ortho.,
> PMC Faisalabad, Pakistan
>
> Express yourself instantly with MSN Messenger! MSN Messenger
> >

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