Metabolic Bone Disease (Subscribe)  

Discussion: - primary function of 1,25 OH2D3) is to maintain skeletal homeostasis as well as for maintenance of plasma Ca homeostasis; - primary effect of...

Wheeless' Textbook of Orthopaedics

Sections on - Bone multicellular units Calcium supplements: Calcitonin Differential Dx Estrogen: HyperPTH / HypoPTH HypoCa / HyperCa Hypophosphatemic Vitamin D-resistant rickets Hyperthyroidism ...

- generalized pathologic processes in bone can be best understood by understanding how these processes alter the normal sequence of bone remodeling as described in the previous chapter; - bone remodeling occurs in local groups of osteoblasts and...

- contraindicated w/ clinical allergy, must periodically examine urine sediment with chronic use; - for symptomatic Paget's Disease of bone, hypercalcemia, post-menopausal osteoporosis (in addition to supplemental calcium, adequate vitamin D intake, and adequate diet);

calcium content of various supplements: - 8 oz of milk: 250-300 mg (and also contains 100 international units of vitamin D); - 1 gm of calcium is present in ...

Wheeless' Textbook of Orthopaedics Discussion: - physical properties - state in body fluids - calcium is a necessary & important addition to cell membranes, giving strength to these structures and regulating permeability; ...

Wheeless' Textbook of Orthopaedics Discussion: - a disorder which is caused by excessive production of parathyroid hormone which leads to hypercalcemia, recurrent nephrolithiasis, pancreatitis, peptic ulcers, and mental changes; - incidence of approx...

Wheeless' Textbook of Orthopaedics Discussion: - most common cause of hypoparathyroidism is inadvertant damage or removal of the parathyroids during surgical removal of the thyroid; - in idiopathic cases, look for ectodermal...

Wheeless' Textbook of Orthopaedics Discussion: - this is the most frequently encountered form of rickets and consists of a genetic or acquired fault in the handling of phosphate in the proximal tubule; -...

Wheeless' Textbook of Orthopaedics Discussion: - physical properties - state in body fluids - physiologic roles of calcium are well established; - abnormally low concentrations of Ca permit spontaneous discharges of both sensory & motor fibers in ...

Case series using internal fixation. PubMed Abstract Orthopedics. 2005 Jun;28(6):587-92 Chhabra A, Westerlund LE, Kline AJ, McLaughlin R.

- is a type of metabolic bone disease in which the essential problem is a lack of available calcium or phosphorus (or both) for mineralization of newly formed osteoid; - children w/ rickets & adults w/ osteomalacia...

In just 3 years, striking new advances have been made in understanding the molecular mechanisms that govern the crosstalk between osteoblasts/stromal cells and hemopoietic osteoclast precursor cells that leads to osteoclastogenesis. Led first by the discovery of osteoprotegerin (OPG), a naturally occurring protein with potent osteoclastogenesis inhibitory activity, rapid progress...

Wheeless' Textbook of Orthopaedics Discussion: - a chronic progressive disease osteoblasts and osteoclasts which results in abnormal bone remodeling; - etiology, staging, and pathogenesis - prevalence: - uncommon...