Monostotic Fibrous Dysplasia (Subscribe)

Jaffe-Lichtenstein monostotic fibrous dysplasia of bone: Definition(s) via UMLS "A disease of bone marked by thinning of the cortex and replacement of bone marrow by gritty fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC). (From Dorland, 28th ed)" 2 synonyms or equivalents were found. Jaffe-Lichtenstein monostotic fibrous dysplasia ...

Description: A monostotic form of fibrous dysplasia of bone. Constitutional, benign disease of the bones characterised by excessive proliferation of single or multiple circumscribed fibrous lesions, predominantly in the long bones, which predispose to painful bone deformities and pathological fractures, limping, unequal limp length, skull asymmetry, leontiaslike appearance, scoliosis, lordosis, and chest deformity. Irregular macular dermal pigmentation is a variable feature. Onset usually ...

High power view of monostotic fibrous dysplasia of bone •A high power view of a focus of new bone formation in a fibrous dysplasia of bone. •The spicule of bone looks structurally normal, with a normal dense osteoid matrix, and lacunea that contain osteocytes. •Surrounding the fragment of new bone formation is a fibrous matrix containing numerous active fibroblasts. (Description By:T.V.Rajan, M.D. ) (Image Contrib. by:T.V.Rajan, M.D. UCHC )