Nonunion (Subscribe)  

P. K. Beredjiklian, M.D., R. J. Naranja, M.D., R. B. Heppenstall, M.D., C. T. Brighton, M.D., Ph.D., and J. L. Esterhai, M.D.
Abstract: The purpose of this study is to report our experience with the treatment of femoral shaft fracture nonunion and to define poor prognostic indicators in the...

eMedicine 2004 Patel Updated 2009
Synonyms and related keywords: tibial delayed union, aseptic nonunion, infected nonunion, tibial fractures, fractures of the tibia, nonunions of the tibia, broken leg, leg fracture, delayed healing, hypertrophic nonunions, atrophic nonunions, normotrophic nonunions, long bone fractures

A bone graft material is any implanted material that, alone or in combination with other material, promotes a bone healing response by osteogenic, osteoinductive or osteoconductive activity at a local site

Approximately 10% of the 7.9 million annual fracture patients in the United States experience nonunion and/or delayed unions, which have a substantial economic and quality of life impact. A variety of devices are being marketed under the name of “bone growth stimulators.” This article provides an overview of electrical and...

Numerous studies have described the use of osteogenic protein-1 (OP-1) in adults, but there are few reports in children. The objectives of this short-term followup cohort study were (1) to examine clinical and radiographic healing of persistent nonunions after OP-1 application in children; and (2) to determine the safety of...

Account of the biology and treatment of nonunion
Signals
• Growth factors, like PDGF, TGF-ß, VEGF, bFGF, etc..
• Released by platelets upon activation
Cells
• Stem cells (mesenchymal)
• Available in bone marrow aspirate

Presentation on the results of use of the Lipus device (Exogen)

Lecture by M Catagni

The purpose of this paper is to determine whether a pre-operative bone biopsy should be done in all cases of non-union of long bones.
Methods. We reviewed the cases of 26 adults over a period of nineteen months. [It is departmental protocol to do a routine biopsy in all cases of...

An Expert Interview With Dr. Thomas Einhorn
Stem cell research has caused much public controversy, sparking debate on ethics, cost, and legislation. Advocates of stem cell research believe that the use of adult stem cells holds promise of widespread applications, especially in the area of orthopaedics. Pippa Wysong of Medscape sat with...

Illustrated discussion of the treatment of tibial nonunions by the Ilizarov method

In this prospective study, we compared outcomes after repair of humeral nonunions when morsellized fresh-frozen allograft or autograft was used to augment repair by intramedullary nailing.
We concluded that when used in association with locked nailing for humeral nonunions, allografts can achieve treatment results similar to autografts but without donor...

Classification and management of nonunion of the humerus

Classification and management of tibial nonunion
definition: no evidence of healing over 3 months;
- FDA definition: frx that is over 9 months old and that has not shown radiographic signs of progression toward healing for 3 consecutive months;
...

Overview, classification and management of nonunion
frx of shaft of long bone should not be considered nonunion until at least 6 months post injury, esp treatment was complicated by infection;
- in contrast, a central fracture of the femoral neck can sometimes be defined as a non union...