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Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic...

2/3rds were spine surgery patients. The study shows that control of blood glucose levels and management of pain during local anesthesia and in the immediate postoperative period can reduce unexpected POD and help preventing unexpected medicolegal problems and economic burdens.
Incidence and Risk Factors of Acute Postoperative Delirium in Geriatric Neurosurgical...

Avoiding postoperative delirium would require anesthetics that preserve cerebral autoregulation. However, that seems a quixotic goal given the intimate connection between neuronal activity and the surrounding capillary network. Perhaps the best approach currently is to avoid other pre-operative medications that disrupt cerebral autoregulation, although such nuances are at the frontier...

BACKGROUND: Postoperative delirium is a frequent and serious complication in elderly patients following operation for hip fracture, leading to an increased risk of complications. The pathophysiological mechanisms are unresolved, but probably multifactorial. The purpose of this review is to summarize current knowledge about the pathogenesis of postoperative delirium with a...

Correspondence.
Postoperative delirium--a challenge for the orthopedic team. Gustafson Y. Acta Orthop Scand. 2004 Aug;75(4):375-7.

Editors' note: this is a plan of a study not the study itself
Delirum is common in hospitalized elderly patients and may be associated with increased morbidity, length of stay and patient care costs. Delirium (acute confusional state) is defined as an acute disorder of attention and cognition. In elderly patients,...

Delirium is a common but often undiagnosed complication in the elderly following a major operation. Recognizing the presentation of delirium and the criteria to establish the diagnosis of delirium will improve a clinician’s ability to detect this complication. Treating delirium with environmental, supportive, and pharmacologic interventions reduces the incidence and...

Trials Register
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves overall pain control.
Ottawa Hospital Research Institute Pfizer

Delirium is a common postoperative complication in older adults associated with adverse events including functional decline, longer lengths of stay, and risk of institutionalization. The purpose of this article is to systematically review preoperative risk factors associated with delirium following noncardiac surgery.
A medical literature search was conducted using several bibliographic...

Logistic regression analysis showed that central nervous system disorder (OR 6.480), surgical history (OR 3.499), age older than 65 years (OR 3.390), diabetes mellitus (OR 2.981), transfused 800 mL or more blood (OR 2.537), and hemoglobin less than 100 g/L (OR 0.281) were significantly related to the occurrence postoperative delirium....

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Objectives: To evaluate risk factors for postoperative delirium in a cohort of elderly hip-surgery patients and to validate a medical risk stratification model.
Results: Incidence of delirium was 3.8% in the low-risk group (P <.001), 11.1% in the intermediate-risk group (P = .27, relative risk (RR) = 3.0), and 37.1%...

Delirium (acute confusional state) may be the most common postoperative complication in elderly people. It is associated with substantial morbidity, mortality and cost.1 Two decades ago, the prevalent belief was that it was normal for older patients to be a “bit confused” after surgery. Now, delirium is recognized as an...