Fibrosarcoma (Subscribe)  

Fibrosarcoma accounts for fewer than 5% of bone sarcomas and 10% of all musculoskeletal sarcomas. It is a malignant spindle-cell neoplasm of mesenchymal origin that demonstrates fibroblastic differentiation and produces a collagen rich fibrous tissue matrix. The spindle cells and matrix are characteristically arranged as intersecting fascicles that...

Fibrosarcoma is a malignant fibroblastic tumor characterized by interlacing bundles of collagen fibers. This sarcoma may occur in various soft tissues, as well as, in bone. In the past 40 years diagnostic criteria have been established to better define its pathological characteristics. At one time all highly cellular, collagen-forming spindle...

Fibrosarcoma is a tumor of mesenchymal cell origin that is composed of malignant fibroblasts in a collagen background. It can occur as a soft-tissue mass or as a primary or secondary bone tumor. Fibrosarcoma was diagnosed much more frequently in the past; it is now more reliably distinguished histologically from...

40 year old, painful shoulder with axillary swelling. There is a purely destructive lesion of the medial side of the proximal metaphysis of the right humerus and involving the inferior portion of the articular surface of the upper humerus. It is associated with a visible medial soft tissue mass. The endosteal...

Discussion: - fibrosarcoma of bone occurs most often in adolescents or young adults; - presents in major long bones, presenting as painful mass; - preoperative staging studies are needed to differentiate low grade ...

J Bone Joint Surg Br. 1985 Jan;67(1):111-6
Taconis WK, van Rijssel TG. A study was made of the clinical course of 102 cases of fibrosarcoma of long bones. Of these, 55 were predominantly fibroblastic or pure fibrosarcomata while 47 contained extensive areas resembling so-called malignant fibrous histiocytoma (MFH). Treatment was similar...

Discussion: - an invasive, malignant, spindle cell tumor which demonstrates cellular atypia, mitosis, & formation of type I collagen; - it is less aggressive in soft tissue than in bone; - most...

Fibrosarcoma Pre-test and tutorial Frank J. Frassica, MD Professor of Orthopaedics & Oncology Johns Hopkins University Department of Orthopaedic Surgery Baltimore, Maryland Franklin H. Sim, MD Chief, Section of Orthopedic Oncology Mayo Clinic Rochester, Minnesota Section of Orthopedics Hyperguide

Radiology case 439-372 Woman aged 50 years with swelling of the left hand.
There is separation of the heads of the metacarpals of index and middle fingers. The soft-tissue is thus expanded. There is irregular periosteal thickening of the cortex of the 2nd and 3rd metacarpals, implying a perisoteal reaction.

Illustrated cases

J Bone Joint Surg Br. 1979 Aug;61-B(3):366-72
Fibrosarcomata and malignant fibrous histiocytomata arising in relation to enchondromata.Sanerkin NG, Woods CG. Six cases are reported in which a fibrosarcoma or malignant fibrous histiocytoma developed in relation to an enchondroma in a long bone. Four of the tumours were fibrosarcomata, and two were...

This is a rare soft tissue sarcoma which predominately occurs on acral sites. These tumors vary in size from a few centimeters to almost 20 centimeters. They typically occur on hands and feet, usually around the ankles or wrists. They are slow growing and painless. Treatment usually is complete excision....

Fibrosarcoma is fairly rare. It has a peak incidence of 35 yrs. It usually starts in the bone and 80% of cases occur around the knee. Some of these cases will be in the soft tissue. Flat bone involvement is unusual. The tumour is usually a medullary lesion, although it...

fibrosarcoma