Rhabdomyosarcoma (Subscribe)  

Illustrated case

This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, staging, and treatment of childhood rhabdomyosarcoma.
The National Cancer Institute provides the PDQ pediatric cancer treatment information summaries as a public service to increase the availability of evidence-based cancer information to health professionals, patients, and the public....

Cellular Classification:-
Embryonal Rhabdomyosarcoma
Botryoid and spindle cell subtypes
Alveolar Rhabdomyosarcoma
Pleomorphic (Anaplastic) Rhabdomyosarcoma

Chromosomal and Molecular Characteristics
Rhabdomyosarcoma can be divided into several histologic subsets: embryonal rhabdomyosarcoma, which has embryonal, botryoid, and spindle cell subtypes; alveolar rhabdomyosarcoma; and pleomorphic rhabdomyosarcoma.

Staging of rhabdomyosarcoma is relatively complex. The process includes:
Assigning a local tumor Group (status postsurgical resection/biopsy).
Assigning stage (consider site, size, Group, presence/absence of metastases).
Assigning a risk group (consider stage, Group, and histology). This page gives details of the staging system used by the Soft Tissue Sarcoma Committee of the Childrens...

Treatment Option Overview All children with rhabdomyosarcoma require multimodality therapy with systemic chemotherapy, in conjunction with either surgery, radiation therapy, or both modalities for local tumor control.[1-3] This entails surgical resection, if feasible without major functional/cosmetic impairment, followed by chemotherapy.

Previously Untreated Childhood Rhabdomyosarcoma
Surgical Management Treatment Options

• Head and neck
• Extremity sites
• Truncal sites
• Genitourinary system
...
[Categories]
- OCOSH Classification: Orthopaedic Oncology: Connective and Soft Tissue Neoplasms: Muscle Tissue Neoplasms: Myosarcoma: Rhabdomyosarcoma 

Recurrent Childhood Rhabdomyosarcoma
Although patients with recurrent or progressive rhabdomyosarcoma can sometimes achieve complete remission with secondary therapy, the long-term prognosis for most is poor. The prognosis is most favorable (50%–70%, 5-year survival rates) for children who initially presented with stage 1 or Group I disease and embryonal histology and whohave local or regional recurrence....

Illustrated cases

Rhabdomyosarcoma is a malignant tumor of striated muscle origin. According to Rubin, it is derived from primitive mesenchyme that retained its capacity for skeletal muscle differentiation. Rhabdomyosarcoma of the head and neck is primarily a disease of the first decade of life, and it is the most common soft tissue...

Illustrated cases

International Journal of Surgical Pathology, Vol. 6, No. 2, 61-71 (1998) Primary Rhabdomyosarcoma Mimicking a Small Cell Sarcoma of Bone: A Nude Mice Xenograft, Cytogenetic, and Molecular Approach A. Llombart-Bosch, MD et al.
Small cell sarcomas of bone are difficult to classify and diagnose. The present case deals with such a tumor...

Several distinct histologic groups have prognostic significance, including embryonal RMS (ERMS, which occurs in 55% of patients), the botryoid variant of ERMS (5% of patients), alveolar RMS (ARMS, 20% of patients), and undifferentiated sarcoma (UDS, 20% of patients). Treatment responses and prognoses vary widely depending on location and histology. Studies...

Description and images of different types of RMS

Rhabdomyosarcoma is the commonest form of soft tissue sarcomas encountered in children, accounting for 4 to 8% of pediatric cancers. The median age of diagnosis is 5 years. There are two main histological subtypes of rhabdomyosarcoma: embryonal (80% of cases) and alveolar (15-20% of cases). Rhabdomyosarcoma is a malignant tumor...

Article from pediatric head and neck surgeons gives information on the general condition, staging etc
Rhabdomyosarcoma is a malignant tumor of striated muscle origin. According to Rubin, it is derived from primitive mesenchyme that retained its capacity for skeletal muscle differentiation. Rhabdomyosarcoma of the head and neck is primarily a disease...