Multiple Myeloma (Subscribe)  

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List risk factors for multiple myeloma.
Describe recommendations for treatment with bisphosphonates for patients with multiple myeloma.
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Multiple Myeloma and Other Plasma Cell Neoplasms (PDQ®): Treatment
Multiple myeloma is a systemic malignancy of plasma cells that is highly treatable but rarely curable. It is potentially curable when it presents as a solitary plasmacytoma of bone or as an extramedullary plasmacytoma. The median survival in the prechemotherapy era was...

* most common primary malignant neoplasm of bone
* 50-70y; M:F 2:1
* symptoms: vague bone pain of progressive severity, fever, anemic sxs
* complications: pathologic fractures
* solitary plasmacytoma: solitary osseous focus of MM (uncommon)
x-ray findings:
* loss of bone density - from diffuse marrow involvement
* "punched out" lesions - esp. skull, long bones
*...

Radiology case 418-3452 Female patient aged 50 years with backache and proteinuria. Recent pain in right humerus after a fall.
There are lytic areas in the metaphysis and diaphysis of the right humerus. Similar distributed lytic areas are present in the clavicle, scapula and ribs. The lytic lesions are predominantly in...

Radiology case 48--3452 Clinical presentation: 42 year old male with an 8 month history of increasing back pain. Had been bed-ridden for the last 3 weeks. The serum calcium was markedly elevated.
The plain film view of the pelvis shows extensive patchy bone destruction. The lytic areas undermine the cortex at various...

Illustrated case

Incidence, Clinical, Xrays, Investigation, Pathology, Treatment, Prognosis

Illustrated cases. See also on this site - Multiple myeloma pseudotumor (Fibrogenesis imperfecta ossium)

Discussion: - myeloma is malignant tumor of plasma cells arising from a single clone; - multiple myeloma accounts for> 40% of primary malignant tumors of bone. - it is most common malignant primary tumor of bone -...

Multiple Myeloma is a neoplasm of differentiated plasma cells resulting from malignant clonal expansion and overproduction of monoclonal immunoglobulins. Common complications include recurrent bacterial infections, anemia, osteolytic lesions and renal insufficiency. Diagnostic Radiology/Musculoskeletal Imaging/Tumors Basic/Multiple Myeloma From Wikibooks, the open-content textbooks collection

destruction is widespread and obvious. Close inspection Multiple Myeloma of the largest lesion shows it to be purely lytic, without any matrix or calcification. There are numerous "tear-drop" shaped lytic lesions in the Multiple Myeloma left femur. Pathologic fracture of the neck of the femur can be clearly seen.
For all...

Multiple myeloma (MM) is characterized by neoplastic proliferation of plasma cells involving more than 10% of the bone marrow. The disease results in the production of monoclonal immunoglobulins, which may be identified with serum protein electrophoresis (SPEP) or urine protein electrophoresis (UPEP). Plasma-cell proliferation causes extensive skeletal destruction with osteolytic...

Orthopedics Hyperguide

Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and mortality. It is the result of increased activity of osteoclasts that is not followed by reactive bone formation by osteoblasts. Recent studies have revealed novel molecules and pathways...

Plasmacytoma amd multiple myeloma are both patterns of bone destruction, produced by an accumulation of plasma cells. The disease occurs in late middle age with a peak incidence at 60 years. Males are more likely to be affected, 2:1. The single mass of plasmacytoma is lytic and expands the bone...