Myositis Ossificans (Subscribe)  

Fibrodysplasia ossificans progressiva is a rare genetic disease characterized by widespread soft tissue ossification and congenital stigmata of the extremities. We report on a male child followed for ten years since the age of 3 years and 9 months, when the diagnosis was made. He was born with bilateral hypoplasic...

Neurogenic myositis ossificans is a disabling condition affecting the large joints of patients with severe post-traumatic impairment of the central nervous system. It can result in ankylosis of the joint and vascular or neural compression. Surgery may be hazardous with potential haemorrhage, neurovascular injury, iatrogenic fracture and osteochondral injury. We...

Medicine On-Line Images in Radiology LT Kendall Lane MD MC USN
A 19 year-old otherwise healthy male presented with right thigh pain for three weeks after another player’s knee struck him playing basketball. During the first week following the injury, he noted significant improvement in the pain with...

Genetics Home Reference Page on this rare genetic condition

Myositis ossificans traumatica of the hand M. Chadha, A. Agarwal Can J Surg, Vol. 50, No. 6, December 2007
We report a rare case of traumatic myositis ossificans occurring in extensor tendon sheaths of the hand and the wrist region in a 10-year-old boy.swelling in the elbow region and on the dorsum...

The literature is devoid of any report concerning ectopic bone formation in traumatic brain injury with simultaneous bony trauma to the affected arm. This article presents a case of a patient with a chronic rigidly ankylosed elbow secondary to heterotopic ossification, after suffering a traumatic brain injury, complex periarticular elbow...

his review focuses on myositis ossificans circumscripta. This is a solitary, non-progressive , benign ossifying condition of the soft tissues, synonymous with heterotopic ossification. This is not to be confused with fibrodysplasia (myositis) ossificans progressiva which is a rare, inherited fibrosing and ossifying disorder of multiple soft tissue...

Physical Medicine. In 1918, Dejerine and Ceillier first described heterotopic ossification (HO) in paraplegic patients injured in World War I, referring to the process as paraosteoarthropathy. HO has been defined as the formation of mature lamellar bone in soft tissues. The process involves true osteoblastic activity and bone formation. HO...

Heterotopic ossification (HO) following spinal cord injury (SCI) was described first by Dejerine and Ceillier in 1918 as paraosteoarthropathy. The process is one of formation of mature lamellar bone, which is indistinguishable from normal bone, in soft tissues surrounding paralyzed joints. The bone is not connected to periosteum and becomes...

Radiology. Heterotopic ossification (HO) is the abnormal formation of true bone within extraskeletal soft tissues. Classically, many diseases sharing this common feature were lumped under the category of myositis ossificans, a term that has fallen into disfavor because primary muscle inflammation is not a necessary precursor and ossification does not...

Bone morphogenic proteins (BMPs) are potent osteoinductive agents. Their use in fracture surgery is still being studied and the clinical indications are evolving. Heterotopic bone after BMP use in spine surgery is a known complication. While some literature describes the ability of BMP to enhance fracture healing, few articles describe...

Spinal Cord Injury - InfoSheet #12 "Heterotopic Ossification"
Level -Professional Date: June, 1997
Heterotopic ossification (HO) is the development of bone in abnormal areas, usually in soft tissues. Heterotopic ossification develops most commonly in individuals who have an injury, such as spinal cord injury, that results in neurologic deficits. It is therefore referred to...

Pediatric Fibrodysplasia Ossificans Progressiva (Myositis Ossificans) * Author: Robert J Pignolo, MD, PhD
Myositis ossificans is a misnomer and the term fibrodysplasia ossificans progressiva (FOP), as used by McKusick, is preferred. It is a rare autosomal dominant disorder characterized by skeletal malformation and progressive, disabling heterotopic osteogenesis....

The small GTPase Rho and Rho-associated protein kinase (Rho kinase, ROCK) signal participates in a variety of biological functions including vascular contraction, tumor invasion, and penile erection. Evidence also suggests Rho-ROCK is involved in signaling for mesenchymal cellular differentiation. However, whether it is involved in osteoblastic differentiation is unknown. We...

The historical terms for heterotopic ossification have been superseded, but ectopic ossification and myositis ossificans are used interchangeably with the term heterotopic ossification. The condition may affect the bones or the joints. Three types of heterotopic ossification have been described: myositis ossificans progressiva (a rare pediatric metabolic disease whereby skeletal...