Orthopedics > OCOSH Classification > Bone Diseases > Orthopaedic Oncology > Connective and Soft Tissue Neoplasms > Muscle Tissue Neoplasms > Alveolar Soft Part Sarcoma

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A variety of sarcoma having a reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue. It is a rare tumor, usually occurring between 15 and 35 years of age. It appears in the muscles of the extremities in adults and most commonly in the head and neck region of children. Though slow-growing, it commonly metastasizes to the lungs, brain, bones, and lymph nodes. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1365)

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Alveolar Soft Part Sarcoma

Location: http://www.thedoctorsdoctor.com/diseases/alveolarsoftparts.htm

Most soft tissue sarcomas have a tendency to metastasize to the lungs, via blood borne dissemination. This sarcoma is one of the few that tends to metastasize to the brain. Sometimes, these metastasis occur has long as 30 years following the discovery of the original tumor. This sarcoma has undergone...
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Alveolar Soft Part Sarcoma

Location: http://ajp.amjpathol.org/cgi/content/full/160/4/1197

Are We at the End or Just the Beginning of Our Quest?
Sharon W. Weiss Commentary American Journal of Pathology. 2002;160:1197-1199.)
These rare tumors with a predilection for the deep soft tissues of the extremities are characterized by an indolent, but inexorably fatal, course often spanning decades. A significant number of...
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Alveolar Soft Part Sarcoma

Location: http://www.alveolarspsarcoma.net/files/asps_metastasis.pdf

Clinical Course and Patterns of Metastasis in 70 patients treated at a single institution.
Cancer Feb 1st 2001; Vol 91 # 3 p585
University of Texas M D Anderson Cancer Center
Conclusion: Long term follow up of patients with localized ASPS reveals a relatively indolent clinical course with relatively low rates of local...
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Alveolar Soft Part Sarcoma

Location: http://atlasgeneticsoncology.org/Tumors/AlveolSoftPartSID5125.html

Atlas of Genetics and Cytogenetics in Oncology and Haematology
involve the musles and soft tissues of the lower extremities in adults (in more than half cases), the head and neck regions in the child, but it can also have extra muscular localizations, such as the female genital tract, the trunk, or...
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Alveolar Soft Part Sarcoma A Case Report JBJS A

Location: http://www.ejbjs.org/cgi/reprint/65/6/841

Brodsky et al JBJS A 1983 65: 841
Case report of an extrinsic soft tissue mass of the thigh treated by hip disarticulation with 5 year follow-up
6 references to the early literature
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Alveolar Soft Part Sarcoma A review and an Update

Location: http://jcp.bmj.com/cgi/reprint/59/11/1127.pdf

The historical, histopathological, ultrastructural, immunochemical and genetic aspects of ASPS are reviewed in this article.
Folpe & Deyrup J. Clin. Pathol 2006; 59; 1127
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Alveolar Soft Part Sarcoma Histopathology India

Location: http://www.histopathology-india.net/AlveolarSoftPartSarcoma.htm

ASPS is a slow growing but, highly malignant tumour. Histogenesis of this tumour has not been established. Some have supported the idea that the tumour represents a distinct variant of rhabdomyosarcoma. However, subsequent studies have failed to demonstrate rhabdomyoblastic differentiation.
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Alveolar Soft Part Sarcoma in Children and Adolescents

Location: http://www.alveolarspsarcoma.net/files/asps_in_children.pdf

A report from the Soft-Tissue Sarcoma Italian Cooperative Group
Annals of Oncology 11: 1445 2000
19 paediatric patients managed over 20 year period. Conclusions: Paediatric ASPS has a more favorable prognosis than its adult counterpart. In this series, tumour size correlates with metastatic disease at onset and is the major factor influencing...
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Alveolar Soft Part Sarcoma in Japan

Location: http://www.alveolarspsarcoma.net/files/japanese_asps_study.pdf

Multi-institutional Study of 57 patients from the Japanese Musculoskeletal Oncology group.
Oncology 2003: 65; 7
Conclusion: ASPS can present primarily as a bone tumor. No advantage with chemotherapy could be demonstrated
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Alveolar Soft Part Sarcoma of the Elbow

Location: http://www.ijri.org/article.asp?issn=0971-3026;year=1999;volume=9;issue=1;spage=32;epage=33;aulast=S ...

Sreedevi I, Naidu GS, Sunderam C, Narendranath L. Alveolar soft part sarcoma of the elbow. Indian J Radiol Imaging 1999;9:32-33
We wish to report a case of an alveolar soft part sarcoma of the right elbow. A forty-five years old woman presented with a profusely bleeding wound and a swelling of the...
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Alveolar Soft Part Sarcoma PMJ

Location: http://pmj.bmj.com/cgi/content/abstract/64/751/386

Alveolar soft-part sarcoma: a hormone-sensitive tumour? Postgraduate Medical Journal, 1988, Vol 64, 386-388
Alveolar soft-part sarcoma is a rare, slow-growing, malignant tumour which metastasizes frequently to the lungs. Treatment with radiotherapy or chemotherapy is largely ineffective, and most patients die within 4 years of developing metastases. We report an unusual patient...
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Collection of Alveolar Soft Part Sarcoma Tumor Specimens for Research

Location: http://clinicaltrials.gov/show/NCT00340353

This study will collect tumor specimens from patients undergoing surgical treatment for alveolar soft part sarcoma (ASPS). This rare, slow-growing cancer originates in soft connective tissues of the body. It most often first appears in the thigh or legs, but may originate in the head and neck. ASPS can metastasize...
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Cure Alveolar Soft Part Sarcoma International

Location: http://www.cureasps.org/

Patient Support Group
Yosef Landesman, Ph.D. President & Cancer Research Director Cure Alveolar Soft Part Sarcoma International (iCureASPS) Patient Provider
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Peripheral Alveolar Soft Part Sarcoma

Location: http://proceedings.jbjs.org.uk/cgi/content/abstract/88-B/SUPP_II/299-d

TWO CASES OF PERIPHERAL ALVEOLAR SOFT PART SARCOMA: PRESENTATION, TREATMENT AND OUTCOMES
G S Nandhara; L Babu; A B Y Ng; and A S Paul University Department of Orthopaedic Surgery, Manchester Royal Infirmary
Purpose: Many cases of Alveolar Soft Part Sarcoma have been reported on the trunk or head and...
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