Osteosarcoma (Subscribe)  

Wide resection and mobile joint reconstruction are preferable for treating an osteosarcoma around the knee. In certain situations, resection arthrodesis or an amputation is suggested. This study compares the outcome in these three groups (not randomized so liable to selection bias (OWL editor))
CONCLUSIONS: The importance of early and proper planning...

A retrospective study of patients with osteosarcoma was undertaken to determine whether there was a relationship between biopsy and survival. Twenty-four of the fifty-seven patients had an amputation without a prior biopsy; the others had biopsies before amputation. These two groups were fairly closely matched in age, sex, site and...

The addition of muramyl tripeptide (MTP) to conventional chemotherapy for the treatment of osteosarcoma reduces mortality by about 30%, according to findings from long-term follow-up of a phase III trial.
Medscape summary of Meyers et al J Clin Oncol 2008;26:633-638.

Osteosarcoma is the most common primary malignant tumor of bone, excluding plasma cell myeloma. Classic, or conventional, osteosarcoma represents the most common variant of osteosarcoma, accounting for approximately 75% of all lesions. Osteosarcoma can affect any bone and is treated by a combination of surgical excision and chemotherapy.
Synonyms and related...

Discussion: - malignant tumor of bone in which neoplastic osteoid is produced by a proliferating spindle cell stroma; - most common primary malignant bone tumor of mesenchymal derivation; - arises in adolescents & affects males slightly more often...

Although advances have been made in both surgical and medical management of patients with osteosarcoma, the overall survival of patients with osteosarcoma has remained constant, with no substantial improvement in the past 15 years. Advances in imaging have had a substantial impact on surgical planning and staging. These advances have,...

Section of Orthopedics Hyperguide

Osteosarcoma of bone is a high-grade tumor with a long-term survival rate of 60-85%. Several variants of osteosarcoma exist. High-grade variants include telangiectatic osteosarcoma, small-cell osteosarcoma, high-grade surface osteosarcoma, and secondary osteosarcoma. Other variants, such as low-grade central osteosarcoma, parosteal osteosarcoma, and periosteal osteosarcoma, are less aggressive entities with a...

Osteosarcoma is the most common malignant primary neoplasm of bone. Orthopedic procedures are essential components in the multidisciplinary treatment of osteosarcoma. Limb-salvaging procedures offer adequate disease control comparable to the results obtained by amputations. This review discusses the advantages and disadvantages of the various types of amputations and the limb-salvaging...

Osteosarcoma is the most common malignant primary bone tumor. Osteosarcoma tends to occur in children and young adults typically 10-25 or 30 years of age. Osteosarcomas also tend to occur in patients in the sixth decade, likely related to malignant degeneration of Paget's disease. It is said that they tend...

This is one of the most common primary bone tumors usually presenting within the first two decades of life. It presents in long bones during periods of the most active bone growth. It most commonly presents with pain and soft tissue swelling of 1-8 months duration. Surprisingly, pathologic fractures are...

This article focuses on high-grade intramedullary osteosarcoma (also referred to as simply osteosarcoma), including its classic osteoblastic form and its fibroblastic and chondroblastic forms. Osteosarcoma is the most common malignant bone tumor.1, 2 This disease is thought to arise from primitive mesenchymal bone-forming cells, and its histologic hallmark is the...

Osteosarcoma is the third most common cancer in adolescence, occurring less frequently than only lymphomas and brain tumors. It is thought to arise from a primitive mesenchymal bone-forming cell and is characterized by production of osteoid. The mainstay of therapy is removal of the lesion. Limb-sparing procedures can often be...

Radiology case 444-3221 5 year old boy with with swelling of the right thigh.
The density of the diaphysis is expanded to an oval by dense thickening of the bone with a centre of radius in mid-diaphysis. There is an additional adjacent soft tissue mass, which has displaced normal muscles. The...

Radiology case 415-3221 16 year old girl with painful swollen right shoulder.
There is a reduced bone density in the proximal metaphysis and the fusing epiphysis of the right humerus. The endosteal margin of the lesion in the diaphysis is ill-defined with a wide zone of transition between normal and abnormal...