Osteosarcoma (Subscribe)  

The addition of muramyl tripeptide (MTP) to conventional chemotherapy for the treatment of osteosarcoma reduces mortality by about 30%, according to findings from long-term follow-up of a phase III trial.
Medscape summary of Meyers et al J Clin Oncol 2008;26:633-638.

Osteosarcoma is the most common primary malignant tumor of bone, excluding plasma cell myeloma. Classic, or conventional, osteosarcoma represents the most common variant of osteosarcoma, accounting for approximately 75% of all lesions. Osteosarcoma can affect any bone and is treated by a combination of surgical excision and chemotherapy.
Synonyms and related...

Discussion: - malignant tumor of bone in which neoplastic osteoid is produced by a proliferating spindle cell stroma; - most common primary malignant bone tumor of mesenchymal derivation; - arises in adolescents & affects males slightly more often...

Section of Orthopedics Hyperguide

Osteosarcoma of bone is a high-grade tumor with a long-term survival rate of 60-85%. Several variants of osteosarcoma exist. High-grade variants include telangiectatic osteosarcoma, small-cell osteosarcoma, high-grade surface osteosarcoma, and secondary osteosarcoma. Other variants, such as low-grade central osteosarcoma, parosteal osteosarcoma, and periosteal osteosarcoma, are less aggressive entities with a...

Osteosarcoma is the most common malignant primary neoplasm of bone. Orthopedic procedures are essential components in the multidisciplinary treatment of osteosarcoma. Limb-salvaging procedures offer adequate disease control comparable to the results obtained by amputations. This review discusses the advantages and disadvantages of the various types of amputations and the limb-salvaging...

Osteosarcoma is the most common malignant primary bone tumor. Osteosarcoma tends to occur in children and young adults typically 10-25 or 30 years of age. Osteosarcomas also tend to occur in patients in the sixth decade, likely related to malignant degeneration of Paget's disease. It is said that they tend...

This is one of the most common primary bone tumors usually presenting within the first two decades of life. It presents in long bones during periods of the most active bone growth. It most commonly presents with pain and soft tissue swelling of 1-8 months duration. Surprisingly, pathologic fractures are...

This article focuses on high-grade intramedullary osteosarcoma (also referred to as simply osteosarcoma), including its classic osteoblastic form and its fibroblastic and chondroblastic forms. Osteosarcoma is the most common malignant bone tumor.1, 2 This disease is thought to arise from primitive mesenchymal bone-forming cells, and its histologic hallmark is the...

Osteosarcoma is the third most common cancer in adolescence, occurring less frequently than only lymphomas and brain tumors. It is thought to arise from a primitive mesenchymal bone-forming cell and is characterized by production of osteoid. The mainstay of therapy is removal of the lesion. Limb-sparing procedures can often be...

Primary tumour arising from bone and producing bone with variants depending on the appearance of the prominent cell type (may look like a fibrosarcoma, chondrosarcoma or myxosarcoma)

Osteosarcoma/Malignant Fibrous Histiocytoma of Bone (PDQ®): Treatment
This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, and treatment of osteosarcoma and malignant fibrous histiocytoma of bone.

Osteosarcoma is the most common primary malignant tumor of bone, excluding plasma cell myeloma. Approximately 75% of all osteosarcomas are of the classic or conventional type, and the remaining 25% comprise the osteosarcoma variants, which are the subject of this article. The variants are a heterogeneous group of osteosarcomas with...

Authors: Joseph Lane, M.D. and Reuven B. Minkowitz, New York, NY The purpose of this chapter is to provide an overview of the anatomic considerations, natural history, clinical manifestations, diagnosis, prognosis and management of Paget's osteosarcoma.
Outline - I. Introduction II. Historical Perspective III. Anatomic and Physciologic Considerations IV. Natural History and...

Brief notes on Incidence, Pathology and Prognosis