Orthopedics > OCOSH Classification > Bone Diseases > Bone Developmental Diseases > Osteochondrodysplasia > Acquired Hyperostosis Syndrome

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Syndrome consisting of synovitis, acne, palmoplantar pustulosis, hyperostosis, and osteitis (SAPHO). The most common site of the disease is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions, hyperostosis, and arthritis of the adjacent joints. The association of sterile inflammatory bone lesions and neutrophilic skin eruptions is indicative of this syndrome. Synonyms SAPHO Syndrome
MeSH Term "Acquired Hyperostosis Syndrome"[mesh] [OCOSH Code: D020083_bd_dbd_ocdys_ahs]

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Acne Arthritis Case Report

Location: http://www.hopkins-arthritis.som.jhmi.edu/case/case1/1_case.html

Our patient's presentation is consistent with the syndrome known as SAPHO (synovitis, acne, pustulosis, hyperostosis and osteomyelitis), and formerly termed acne arthritis. The syndrome is characterized by severe scarring acne and related conditions; hyperostotic bone lesions (particularly in the clavicles and sternum); sacroiliitis; spondylitis; and, peripheral inflammatory arthritis.
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Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation

Location: http://arthritis-research.com/content/11/5/R140

The acronym SAPHO was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. The etiology of SAPHO syndrome is unknown, an association with infection by semipathogenic bacteria like...
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Pubmed Search for Acquired Hyperostosis Syndrome

Location: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=%22Acquired+Hyperostosis+Syndrome%22%5B ...

Search String "Acquired Hyperostosis Syndrome"[MAJR] URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=%22Acquired+Hyperostosis+Syndrome%22%5BMAJR%5D 111 articles Nov 2006
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SAPHO syndrome

Location: http://arthritis-research.com/content/pdf/ar2837.pdf

SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne...
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SAPHO Syndrome MedicineNet

Location: http://www.medicinenet.com/sapho_syndrome/article.htm

SAPHO Syndrome At A Glance SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. Some researchers feel that the SAPHO syndrome is related to the group of arthritis conditions which typically affect the...
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Sapho Syndrome Orphanet

Location: http://www.orpha.net/data/patho/GB/uk-sapho.pdf

Review by Prof. Fritz Schilling Definition - SAPHO syndrome is a disease combining osseaous and articular manifestations associated with skin manifestations. Three diagnostic criteria characterize SAPHO sydrome: 1. multifocal osteitis with or without skin manifestations 2. Sterile acute or chronic joint inflammation associateted with either pustules or psoriasis of thepalms and soles, or...
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SAPHO syndrome treated with pamidronate

Location: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2005;volume=71;issue=4;spage=273;epage=275;aula ...

Abstract A middle aged man presented with a 4 year history of painful swelling of both knees and pustular acne on his back. The MRI scan of the knees showed gross synovitis, so did the histopathology of the synovium. A diagnosis of SAPHO syndrome was made and he was...
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SAPHO Syndrome Wikbooks

Location: http://en.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Infection/SAPHO_Syndrome

Definition Synovitis Acne -- commonly involving the face and upper back. Pustulosis -- usually involving the palms of the hands and/or soles of the feet (palmo-plantar pustulosis). Hyperostosis Osteitis SAPHO syndrome is thought to comprise a spectrum of disorders that share some clinical, radiologic and pathologic characteristics. An entity known as...
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SAPHO Syndrome Wikipedia

Location: http://en.wikipedia.org/wiki/Acquired_hyperostosis_syndrome

SAPHO syndrome is thought to comprise a spectrum of disorders that share some clinical, radiologic and pathologic characteristics. An entity known as chronic recurrent multifocal osteomyelitis (CRMO) was first described in 1972. Subsequently in 1978 several cases of CRMO were associated with clinical findings of palmoplantar pustulosis. Since then, a... Uncertain
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Synovitis Acne Pustulosis Hyperostosis osteomyelitis syndrome SAPHO

Location: http://www.hopkins-arthritis.som.jhmi.edu/rheumrounds/sapho_rheumrounds7.html

A gentleman comes in complaining of right knee pain. He is a 48-year-old African American man who was transferred from the Infectious Disease Clinic to the Thayer Medical Service for possible septic arthritis. His symptoms essentially limited his right knee motion; he is not able to flex more than 30...
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View Details Visit Resource Review It Rate It Bookmark It Added: Mon Nov 27 2006