Bone multicellular units

Description: - generalized pathologic processes in bone can be best understood by understanding how these processes alter the normal sequence of bone remodeling as described in the previous chapter; - bone remodeling occurs in local groups of osteoblasts and osteoclasts called bone multicellular units (BMU); - each unit is organized into "cutting cone" of osteoclasts reabsorbing bone followed by trail of osteoblasts reforming the bone to fill defect left by osteoclasts; - end product is a new osteon;